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Purified anti-human CD112 (Nectin-2) Antibody

Pricing & Availability
Clone
TX31 (See other available formats)
Regulatory Status
RUO
Other Names
Poliovirus Receptor Related 2 Protein (PRR2), Nectin-2, Hve B
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
TX31_Pure_110308.jpg
KG1a (human myeloid leukemia cell line) stained with purified TX31, followed by biotinylated anti-mouse IgG and Sav-PE
  • TX31_Pure_110308.jpg
    KG1a (human myeloid leukemia cell line) stained with purified TX31, followed by biotinylated anti-mouse IgG and Sav-PE
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337402 100 µg £85
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Description

CD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34 positive stem cells, endothelial cells, epithelial cells, and neuronal cells. CD112 functions as a receptor for α-herpes viruses HSV-1 and pseudorabies virus (PRV). CD112 is an adhesion molecule involved in the formation of cell junction and regulation of NK- and T cell-mediated cytotoxicity through interaction with CD226 (DNAM-1) and other nectin family molecules.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications include: partially block CD226-Fc binding to CD112 transfectant cells and partially inhibit the cytotoxicity mediated by NK and T cells.

Application References

(PubMed link indicates BioLegend citation)
  1. Tahara-Hanaoka S, et al.. 2004. Int. Immunol. 16:533
  2. Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
  3. Gillory LA, 2013. PLoS One. 8:77753. PubMed
RRID
AB_2174164 (BioLegend Cat. No. 337402)

Antigen Details

Structure
Type I transmembrane glycoprotein, Ig superfamily
Distribution

Myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells.

Function
Adhesion, receptor for some Herpes Viruses
Ligand/Receptor
CD226, CD155, Nectin-1, -3, and -4, Herpes Viruses
Cell Type
Dendritic cells, Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors, Mast cells, Megakaryocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Zola H et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Bachelet I, et al. 2006. J. Bio. Chem. 281:27190
3. Pende D, et al. 2006. Blood 107:2030
4. Bottino C, et al. 2003. J. Exp. Med. 198:557

Gene ID
5819 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD112
Specificity Alt (DOES NOT SHOW ON TDS):
CD112
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about CD112 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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