Loading...

Purified anti-mouse CD3ε Antibody

Pricing & Availability
Clone
145-2C11 (See other available formats)
Regulatory Status
RUO
Other Names
CD3ε, T3, CD3
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
145-2C11_Pure_021606
C57BL/6 mouse splenocytes were stained with purified CD3e (clone 145-2C11) (filled histogram) or Armenian hamster IgG isotype control (open histogram), followed by anti-Armenian hamster IgG FITC.
  • 145-2C11_Pure_021606
    C57BL/6 mouse splenocytes were stained with purified CD3e (clone 145-2C11) (filled histogram) or Armenian hamster IgG isotype control (open histogram), followed by anti-Armenian hamster IgG FITC.
  • 145-2C11_PURE_CD3e_Antibody_IHC-F_033017
    C57BL/6 mouse frozen spleen section was fixed with 4% paraformaldehyde (PFA) for ten minutes at room temperature and blocked with 5% FBS for 30 minutes at room temperature. Then the section was stained with 10 µg/mL of purified anti-mouse CD3ε (clone 145-2C11) and 10 µg/mL of Alexa Fluor® 488 anti-mouse/human CD45R/B220 (clone RA3-6B2) (green) overnight at 4°C, followed by 2.5 µg/mL of Alexa Fluor® 594 Goat anti-hamster (Armenian) IgG (clone Poly4055) (red) for two hours at room temperature. The image was captured by 10X objective.
  • 145-2C11_PURE_CD3e_Antibody_IHC-F_2_102518
    Fresh, frozen mouse spleen was stained with purified CD3ε clone 145-2C11 conjugated and detected with a Cy3 CODEX™ oligonucleotide duplex (red). Samples were counterstained with B220 A647 (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology.
Compare all formats
Cat # Size Price Quantity Check Availability Save
100301 50 µg £17
Check Availability


Need larger quantities of this item?
Request Bulk Quote
100302 500 µg £50
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD3ε is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3ε forms a TCR complex by associating with the CD3δ, γ and ζ chains, as well as the TCR α/β or γ/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
H-2Kb-specific mouse cytotoxic T lymphocyte clone BM10-37
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The CD3ε antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F - Verified
IP, Activ, Block, WB, ICC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. For immunohistochemical staining on frozen tissue sections, the suggested use of this reagent is 5.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone 145-2C11 is useful for in vitro blocking of target-specific CTL-mediated cell lysis1, as well as T cell activation assays, inducing proliferation and cytokine production1,2,7,12,16. It also induces apoptosis in immature thymocytes32,  and in vivo T cell depletion8-10. Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1, immunohistochemical staining14,15 of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, Western blotting4, complement-mediated cytotoxicity6, in vitro and in vivo stimulation of T cells1,2,7,12,16, immunofluorescent staining5, and in vivo T cell depletion8-10. The 145-2C11 antibody has been reported to block the binding of 17A2 antibody to CD3 epsilon-specific T cells11. Clone 145-2C11 is not recommended for formalin-fixed paraffin embedded sections. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 100314). For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 100340) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).

Application References

(PubMed link indicates BioLegend citation)
  1. Leo O, et al. 1987. P. Natl. Acad. Sci. USA 84:1374. (IP, Activ, Block)
  2. Kruisbeek AM, et al. 1991. In Current Protocols in Immunology. 3.12.1. (Activ)
  3. Duke RC, et al. 1995. Current Protocols in Immunology. 3.17.1.
  4. Salvadori S, et al. 1994. J. Immunol. 153:5176. (WB)
  5. Payer E, et al. 1991. J. Immunol. 146:2536. (IF)
  6. Jacobs H, et al. 1994. Eur. J. Immunol. 24:934. (CMCD)
  7. Vossen ACTM, et al. 1995. Eur. J. Immunol. 25:1492. (Activ)
  8. Henrickson M, et al. 1995. Transplantation 60:828. (Deplete)
  9. Kinnaert P, et al. 1996. Transpl. Int. 9:386. (Deplete)
  10. Han WR, et al. 1999. Transpl. Immunol. 7:207. (Deplete)
  11. Miescher GC, et al. 1989. Immunol. Lett. 23:113. (Block)
  12. Terrazas LI, et al. 2005. Intl. J. Parasitology. 35:1349. (Activ)
  13. Ko SY, et al. 2005. J. Immunol. 175:3309.
  14. Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC-F)
  15. Tilley SL, et al. 2007. J. Immunol. 178:3208. (IHC-F)
  16. Wang W, et al. 2007. J. Immunol. 178:4885. (Activ)
  17. Xiao S, et al. 2007. J. Exp. Med. 204:1691.
  18. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed.
  19. Curtsinger JM, et al.2005. J. Immunol. 175:4392. PubMed
  20. Guo Y, et al. 2008. Blood 112:480. PubMed
  21. Kenna TJ, et al. 2008. Blood 111:2091.
  22. Perchonock CE, et al. 2007. J. Immunol. 179:1768. PubMed
  23. Perchonock GE, et al. 2006. Mol. Cell. Biol. 26:6005. PubMed
  24. Kanaya T, et al. 2008. Am. J. Physiol. Gastrointest. Liver Physiol. 295:G273. PubMed
  25. de Koning BA, et al. 2006. Int. Immunol. 18:941. PubMed
  26. Schulteis RD, et al. 2008. Blood 295:G273. PubMed
  27. Qi Q, et al. 2009. Blood 114:564. PubMed
  28. Helmersson S, et al. 2013. Am J Pathol. 9440:123. Pubmed
  29. Wu S, et al. 2014. Clin Vaccine Immunol. 21:156. PubMed
  30. Yan J, et al. 2014. Vaccine. 32:2833. PubMed
  31. Guiterrez DA, et al. 2014. Diaebetes. 63:3827. PubMed
  32. Shi YF, et al. 1991. J Immunol. 146:3340. (Apop)
Product Citations
  1. Akiyama C, et al. 2019. J Immunol. 203:835. PubMed
  2. Bergfeld A, et al. 2017. Front Microbiol. 0.919444444. PubMed
  3. Chemnitz J, et al. 2019. Sci Rep. 3.745138889. PubMed
  4. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  5. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  6. Shirai T, et al. 2022. Cancer Sci. 113:3710. PubMed
  7. Giampaolo S, et al. 2023. iScience. 26:106234. PubMed
  8. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  9. Sandu I, et al. 2020. Nat Commun. 11:4454. PubMed
  10. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  11. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  12. Tian J, et al. 2021. Autophagy. 17:2586. PubMed
  13. Tersteegen A, et al. 2021. Infect Immun. 89:. PubMed
  14. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  15. Collin R, et al. 2020. J Immunol. 205:133. PubMed
  16. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  17. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  18. Koenig A, et al. 2022. Front Immunol. 12:791100. PubMed
  19. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  20. Briukhovetska D, et al. 2023. Immunity. 56:143. PubMed
  21. Zhang J, et al. 2023. Int J Nanomedicine. 18:209. PubMed
  22. Elliot TAE, et al. 2022. Discov Immunol. 1:kyac009. PubMed
  23. Schick J, et al. 2023. Elife. 12: . PubMed
  24. Kim K, et al. 2016. PLoS One. 11: 0148576. PubMed
  25. Krovi SH, et al. 2019. Proc Natl Acad Sci U S A. 116:22252. PubMed
  26. Biljes D, et al. 2017. EXCLI J. 0.86875. PubMed
  27. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  28. Kondo H, et al. 2020. J Biol Chem. 295:1658. PubMed
  29. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  30. Boyd DF, et al. 2020. Nature. 587:466. PubMed
  31. Goel S, et al. 2017. Nature. 548:471. PubMed
  32. Field CS, et al. 2018. Oncoimmunology. 7:e1376154. PubMed
  33. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  34. Namavari A, et al. 2012. Invest Ophthalmol Vis Sci . 53:4575. PubMed
  35. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  36. Chen L, et al. 2019. Nat Commun. 3.553472222. PubMed
  37. Sanctuary MR, et al. 2019. Mucosal Immunol. 0.638888889. PubMed
  38. Carpenter SM, et al. 2017. PLoS Pathog. 13:e1006704. PubMed
  39. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  40. Crawford G, et al. 2018. Nat Immunol. 1.388194444. PubMed
  41. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  42. Oghumu S, et al. 2019. J Immunol. 203:789. PubMed
  43. Liang W, et al. 2022. Methods Mol Biol. 2574:221. PubMed
  44. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  45. McLane LM, et al. 2021. Cell Reports. 35(6):109120. PubMed
  46. Arimura K, et al. 2017. Mucosal Immunol. 1.08125. PubMed
  47. Zhou AC, et al. 2017. Front Immunol. 1.136111111. PubMed
  48. Niss Arfelt K, et al. 2017. Blood. 129:866. PubMed
  49. Liu W, et al. 2021. Stem Cell Res Ther. 12:153. PubMed
  50. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  51. Willimsky G, et al. 2021. Elife. 10:. PubMed
  52. Quintana E, et al. 2020. Cancer Res. 80:2889. PubMed
  53. Jennings EK, et al. 2021. STAR Protocols. 2(1):100284. PubMed
  54. Lu SX, et al. 2021. Cell. . PubMed
  55. Edenborough KM, et al. 2019. Front Immunol. 10:2414. PubMed
  56. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  57. Robert S, et al. 2018. Bone Marrow Transplant. 53:807. PubMed
  58. Morabito KM, et al. 2017. Mucosal Immunol. 0.795138889. PubMed
  59. Rissiek B, et al. 2017. Sci Rep. . 10.1038/s41598-017-16613-w. PubMed
  60. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  61. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  62. Tanaka Y, et al. 2021. Int J Mol Sci. 22:. PubMed
  63. Muhammad F, et al. 2020. Front Immunol. 975:11. PubMed
  64. Yi M, et al. 2021. J Hematol Oncol. 14:27. PubMed
  65. Sekiya T et al. 2018. Cell reports. 24(6):1627-1638 . PubMed
  66. Lyon de Ana C, et al. 2019. J Immunol. 202:1112. PubMed
  67. Wu P et al. 2019. Molecular cell. 73(5):1015-1027 . PubMed
  68. Tuzlak S, et al. 2017. Cell Death Differ. 24:523. PubMed
  69. Doorduijn EM, et al. 2018. Front Immunol. 0.416666667. PubMed
  70. Rao TN, et al. 2020. J Immunol. 204:2600. PubMed
  71. Perchonock C, et al. 2006. Mol Cell Biol . 26:6005. PubMed
  72. Guo Y, et al. 2008. Blood. 112:480. PubMed
  73. El Maï M, et al. 2021. Cancers (Basel). 13:. PubMed
  74. Baluk P, et al. 2020. Am J Pathol. 190:2355. PubMed
  75. Mullins GN, et al. 2020. Sci Rep. 10:21994. PubMed
  76. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  77. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  78. Hanoteau A, et al. 2019. J Immunother Cancer. 7:10. PubMed
  79. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  80. Duc D et al. 2019. Cell Rep. 29(2):378-390 . PubMed
  81. Xu L et al. 2017. Immunity. 47(3):538-551 . PubMed
  82. Zhang P, et al. 2022. BMC Med. 20:435. PubMed
  83. Chen Z et al. 2019. Immunity. 51(5):840-855 . PubMed
  84. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  85. Abboud G, et al. 2018. Front Immunol. 9:1973. PubMed
  86. Imani J, et al. 2021. JCI Insight. 6:. PubMed
  87. Xie D, et al. 2020. Eur J Immunol. 50:1729. PubMed
  88. Reed J, et al. 2020. Bio Protoc. 10:e3607. PubMed
  89. Morales-Mantilla DE, et al. 2022. Elife. 11:. PubMed
  90. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  91. McCully M, et al. 2015. J Immunol. 195: 96 - 104. PubMed
  92. Bremser A, et al. 2015. PLoS One. 10: 0137393. PubMed
  93. Cain MP, et al. 2020. Dis Model Mech. 13:00. PubMed
  94. Takushi SE, et al. 2020. Hum Gene Ther. 31:626. PubMed
  95. Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
  96. Di Martino L, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:901. PubMed
  97. James OJ, et al. 2021. Nat Commun. 12:4290. PubMed
  98. Won HY, et al. 2017. Sci Rep. 7:16946. PubMed
  99. Van De Velde LA, et al. 2017. J Biol Chem. 292:15:00. PubMed
  100. Scholz T, et al. 2017. PLoS One. 12:e0182646. PubMed
  101. Sprouse ML, et al. 2018. JCI Insight. 3:e97322. PubMed
  102. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  103. Sharabi A, et al. 2019. JCI Insight. 4:e126294. PubMed
  104. Du J, et al. 2018. AMB Express. 8:158. PubMed
  105. Majer O, et al. 2019. Nature. 575:366. PubMed
  106. Sun L, et al. 2022. Front Immunol. 13:823853. PubMed
  107. Wu G, et al. 2022. Wellcome Open Res. 6:134. PubMed
  108. Otsuka S, et al. 2021. J Clin Invest. 131:. PubMed
  109. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  110. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  111. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  112. Hsieh WC, et al. 2020. JCI Insight. 5:00. PubMed
  113. Sharma M, et al. 2020. Circ Res. 127:335. PubMed
  114. Seo N, et al. 2018. Nat Commun. 9:435. PubMed
  115. Parzmair GP, et al. 2017. J Leukoc Biol. 101:407. PubMed
  116. Kälin S et al. 2017. Cell metabolism. 26(3):475-492 . PubMed
  117. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  118. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  119. Hao Y, et al. 2018. Front Immunol. 9:1127. PubMed
  120. Ma VP, et al. 2022. Sci Adv. 8:eabg4485. PubMed
  121. Li Z, et al. 2021. MBio. 12:e0254221. PubMed
  122. Ejima R, et al. 2021. Nutrients. 13:. PubMed
  123. Becker W, et al. 2021. J Crohns Colitis. 15:1032. PubMed
  124. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  125. Baluk P, et al. 2018. Methods Mol Biol. 1846:161. PubMed
  126. Katagiri T, et al. 2019. Mucosal Immunol. 12:p1104. PubMed
  127. Wang HC, et al. 2017. J Immunol. 198:3149. PubMed
  128. Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed
  129. Klein JC, et al. 2017. Nat Commun. 8:14600. PubMed
  130. Sripada A, et al. 2021. PLoS Biol. 19:e3001063. PubMed
  131. Shiozawa S, et al. 2022. iScience. 25:103537. PubMed
  132. Wu Y, et al. 2021. J Clin Invest. 131:. PubMed
  133. Rigo MM, et al. 2020. FEBS J. :. PubMed
  134. Sandy A, et al. 2013. J Immunol. 190:5818. PubMed
  135. Spranger S, et al. 2017. Cancer Cell. 31:711. PubMed
  136. Wang W, et al. 2018. J Vasc Surg. 68:1538. PubMed
  137. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  138. Lee J, et al. 2020. Cells. 9:. PubMed
  139. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  140. Goh W, et al. 2020. Cell Rep. 33:108285. PubMed
  141. Link MA, et al. 2017. PLoS One. 12:e0184320. PubMed
  142. Teijeira A, et al. 2018. Cancer Immunol Res. 6:798. PubMed
  143. Jiao S, et al. 2020. Cell. 179(5):1177-1190.e13.. PubMed
  144. Aguilar OA, et al. 2020. J Immunol. 205:1709. PubMed
  145. Taylor MD, et al. 2020. Front Immunol. 11:1946. PubMed
  146. Kissiov DU, et al. 2022. Elife. 11:. PubMed
  147. Yoon S, et al. 2022. Nat Commun. 13:1602. PubMed
  148. Fernández-Orth J, et al. 2020. Eur J Immunol. . PubMed
  149. Wagner AK, et al. 2017. Nat Commun. 8:15627. PubMed
  150. Stelekati E, et al. 2018. Cell Rep. 2.445833333. PubMed
  151. Cui X, et al. 2017. J Immunol. 199:4066. PubMed
  152. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
  153. Niven J, et al. 2019. Cell Rep. 28:21. PubMed
  154. Coley WD et al. 2018. F1000Research. 2018 Mar 14 [revised 2018 Jan 1] 0.5125. PubMed
  155. Koch K, et al. 2022. Int J Mol Sci. 23:. PubMed
  156. Yang H, et al. 2022. Cell Death Discov. 8:183. PubMed
  157. Qiu Z, et al. 2022. Cancer Discov. 12:502. PubMed
  158. Sun Y, et al. 2021. Nat Commun. 12:5147. PubMed
  159. Lin Z, et al. 2021. Stem Cells. 39:240. PubMed
  160. Chen Z, et al. 2021. Cell. 184(5):1262-1280.e22. PubMed
  161. Gaspar M, et al. 2020. Cancer Immunol Res. 0.875694444. PubMed
  162. Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
  163. Afzali B, et al. 2017. Nat Immunol. 18:813. PubMed
  164. Cohen MA, et al. 2020. Cell Stem Cell. 26(4):579-592. PubMed
  165. Genoud V, et al. 2018. Oncoimmunology. 7:e1501137. PubMed
  166. Dey P, et al. 2020. Cancer Discov. 10:608. PubMed
  167. Schnoegl D, et al. 2022. Front Immunol. 13:909270. PubMed
  168. Perchonock C, et al. 2007. J Immunol. 179:1768. PubMed
  169. Cole C, et al. 2018. Nucleic Acids Res. 46:e62. PubMed
  170. Abe Y, et al. 2017. Biochem Biophys Rep. 0.543055556. PubMed
  171. Nakamura K, et al. 2018. Cancer Cell. 33:634. PubMed
  172. Lin J, et al. 2017. Nat Commun. . 10.1038/s41467-017-01477-5. PubMed
  173. Taylor MD, et al. 2020. Front Immunol. 11:563402. PubMed
  174. Nagatake T, et al. 2021. Int Immunol. 33:171. PubMed
  175. Sasai M, et al. 2021. J Exp Med. 218:. PubMed
  176. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  177. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  178. Akkaya B, et al. 2018. J Immunol. 201:3294. PubMed
  179. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  180. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  181. Bordoloi D, et al. 2021. Genes Cancer. 12:51. PubMed
  182. Wang W, et al. 2022. Nat Commun. 13:4495. PubMed
  183. Wang G, et al. 2015. PLoS One. 10:121968. PubMed
  184. Kojima T, et al. 2016. Sci Rep. 6:36457. PubMed
  185. Katsuyama T, et al. 2021. Cell Reports. 36(1):109339. PubMed
  186. Kästle M, et al. 2020. Cell Commun Signal. 183:18. PubMed
  187. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  188. Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  189. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  190. Yamazaki K, et al. 2022. Sci Rep. 12:3242. PubMed
  191. Chen YH, et al. 2022. Arthritis Res Ther. 24:27. PubMed
  192. Sutiwisesak R, et al. 2020. PLoS Pathog. 16:e1009000. PubMed
  193. Xia L, et al. 2021. Cancer Immunol Res. 9:707. PubMed
  194. Galeano Nio JL, et al. 2020. eLife. 9:00. PubMed
RRID
AB_312666 (BioLegend Cat. No. 100301)
AB_312666 (BioLegend Cat. No. 100302)

Antigen Details

Structure
Ig superfamily, forms CD3/TCR complex with CD3δ, γ and ζ subunits and TCR (α/β and γ/δ), 20 kD
Distribution

Thymocytes (differentiation dependent), mature T cells, NK-T cells

Function
TCR signal transduction, T cell activation, antigen recognition
Ligand/Receptor
Peptide antigen/MHC-complex
Cell Type
NKT cells, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules, TCRs
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Davis MM. 1990. Annu. Rev. Biochem. 59:475.
3. Weiss A, et al. 1994. Cell 76:263.

Gene ID
12501 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD3epsilon
Specificity Alt (DOES NOT SHOW ON TDS):
CD3ε
App Abbreviation (DOES NOT SHOW ON TDS):
FC,IHC-F,IP,Activ,Block,WB,ICC
UniProt
View information about CD3epsilon on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 10/17/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account