Alexa Fluor 647 anti-human CD307c/FcRL3 Antibody anti-CD307c

Pricing & Availability

Clone: H5/FcRL3 (See other available formats)
Regulatory Status: RUO
Other Names: Fc receptor-like 3 (FCRL3), Immune receptor translocation-associated protein 3 (IRTA3), SH2 domain-containing phosphatase anchor protein 2 (SPAP2), IFGP family protein 3 (IFGP3)
Isotype: Mouse IgG2b, κ
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H5slashFcRL3_A647_CD307c_Antibody_1_121317 — Human peripheral blood lymphocytes were surface stained with CD3 Brilliant Violet 421™ and H5/FcRL3 Alexa Fluor® 647 (top) or Mouse IgG2b, κ Alexa Fluor® 647 isotype control (bottom).

Compare all formats See Alexa Fluor® 647 spectral data

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374407

25 tests

£109

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374408

100 tests

£254

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Description

CD307c is a type 1 transmembrane glycoprotein in the FcRL family of the Ig gene superfamily that is conserved in humans and not found in mice. It is expressed on NK cells, T cell, regulatory T cell, B cell and plasma cell subsets. Intracellular ITAM and ITIM motifs in conjunction with extracellular Ig domains are thought to play a role in the regulation of immune response, and autoimmune function. Impairment of normal FcRL3 function has been linked to systemic lupus erythematosus, rheumatoid arthritis, and autoimmune thyroid disease.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: FcRL3 full length expression plasmid DNA, followed by cell boost using transiently transfected cells with the same plasmid.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

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Excitation Laser: Red Laser (633 nm)
RRID: AB_2721355 (BioLegend Cat. No. 374407)
AB_2721355 (BioLegend Cat. No. 374408)

Antigen Details

Distribution: NK, T, regulatory T, B, and plasma cell subsets.
Interaction: Tyrosine-protein phosphatase non-receptor type 6 (PTPN6).
Cell Type: B cells, NK cells, Plasma cells, T cells, Tregs
Biology Area: Immunology
Molecular Family: CD Molecules, Fc Receptors
Antigen References: 1. Bin Dhuban K, et al. 2015. J. Immunol. 194(8):3687-96.
2. Yuan M, et al. 2016. Mol. Neurobiol. 53:2029-35.
3. Fang Y, et al. 2016. Immunobiology. 221(1):56-62.
Gene ID: 115352 View all products for this Gene ID
UniProt: View information about CD307c/FcRL3 on UniProt.org

Documentation

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD307c/FcRL3 Reagents Request Custom Conjugation

Description	Clone	Applications
PE anti-human CD307c/FcRL3	H5/FcRL3	FC
Ultra-LEAF™ Purified anti-human CD307c/FcRL3	H5/FcRL3	FC
Alexa Fluor® 647 anti-human CD307c/FcRL3	H5/FcRL3	FC
PE/Cyanine7 anti-human CD307c/FcRL3	H5/FcRL3	FC
TotalSeq™-C0826 anti-human CD307c/FcRL3	H5/FcRL3	PG
TotalSeq™-B0826 anti-human CD307c/FcRL3 Antibody	H5/FcRL3	PG

Certificate of Analysis

Go To Top Version: 0 Revision Date: 12/13/2017

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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