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APC anti-human CD126 (IL-6Rα) Antibody

Pricing & Availability
Clone
UV4 (See other available formats)
Regulatory Status
RUO
Other Names
IL-6R1, gp80, IL-6 receptor alpha, IL-6R
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
UV4_APC_1_032312
Human peripheral blood lymphocytes were stained with CD3 PE and IL-6Rα (clone UV4) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • UV4_APC_1_032312
    Human peripheral blood lymphocytes were stained with CD3 PE and IL-6Rα (clone UV4) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • UV4_APC_2_032312
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352805 25 tests £90
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352806 100 tests £232
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Description

CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human myeloma cell line U266
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.

Application References

(PubMed link indicates BioLegend citation)
  1. Huang YW and Vitetta ES. 1993. Hybridoma 12:621.
Product Citations
  1. Ferreira LB, et al. 2023. J Ophthalmic Inflamm Infect. 13:21. PubMed
  2. Domenger A, et al. 2022. EMBO Mol Med. 14:e14740. PubMed
  3. Krow-Lucal E, et al. 2014. Blood. 123:1897. PubMed
  4. Eichten A, et al. 2016. Cancer Res . 76: 2327-2339. PubMed
  5. Theurich S et al. 2017. Cell metabolism. 26(1):171-184 . PubMed
  6. Reyes M, et al. 2021. Sci Transl Med. 13:. PubMed
  7. Wolf J, et al. 2016. J Biol Chem. 291: 16186 - 16196. PubMed
RRID
AB_11204258 (BioLegend Cat. No. 352805)
AB_11204258 (BioLegend Cat. No. 352806)

Antigen Details

Structure
Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD
Distribution

Plasma cells, T cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts

Function
Stimulates T cells, B cells, and hematopoietic precursor proliferation and differentiation
Interaction
CD130, c-Src, STAT3, WWP1, WWP2
Ligand/Receptor
IL-6
Cell Type
B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797.
2. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London.
3. Boulanger MJ, et al. 2003. Science 300:2101.
4. Gaillard JP, et al. 1993. Eur. J. Immunol. 23:820.

Gene ID
3570 View all products for this Gene ID
UniProt
View information about CD126 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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