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APC anti-human CD198 (CCR8) Antibody

Pricing & Availability
Clone
S19016H (See other available formats)
Regulatory Status
RUO
Other Names
CC-CKR-8, C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
S19016H_APC_CD198_Antibody_060922
Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD198 (CCR8) (clone S19016H) APC (left) or rat IgG2b, κ APC isotype control (right).
  • S19016H_APC_CD198_Antibody_060922
    Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD198 (CCR8) (clone S19016H) APC (left) or rat IgG2b, κ APC isotype control (right).
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365807 25 tests £99
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365808 100 tests £227
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Description

CCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human CCR8-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone S19016H induces complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) on CCR8-transfected cells.

RRID
AB_2927839 (BioLegend Cat. No. 365807)
AB_2927839 (BioLegend Cat. No. 365808)

Antigen Details

Structure
Seven hydrophobic transmembrane domains
Distribution

Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons

Cell Type
Tregs
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Tiffany HL, et al. 1997. J Exp Med. 186:165-70.
  2. Goya I, et al. 1998. J Immunol. 160:1975-81.
  3. Lee S, et al. 2000. J Virol. 74:6946-52.
  4. Chensue SW, et al. 2001. J Exp Med. 193:573-84.
  5. Qu C, et al. 2004. J Exp Med. 200:1231-41.
  6. Isolam SA, et al. 2013. J Exp Med. 210:1889-98.
Gene ID
1237 View all products for this Gene ID
UniProt
View information about CD198 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 06/09/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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