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APC anti-human CLEC5A Antibody

Pricing & Availability
Clone
14H4-1-2 (See other available formats)
Regulatory Status
RUO
Other Names
MDL1, MDL-1, CLECSFS
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
14H4-1-2_APC_CLEC5A_Antibody_021822
Human peripheral blood monocytes were stained with anti-human CLEC5A (clone 14H4-1-2) APC (left) or mouse IgG2b, κ APC isotype control (right), followed by anti-human CD14 PE.
  • 14H4-1-2_APC_CLEC5A_Antibody_021822
    Human peripheral blood monocytes were stained with anti-human CLEC5A (clone 14H4-1-2) APC (left) or mouse IgG2b, κ APC isotype control (right), followed by anti-human CD14 PE.
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371709 25 tests £130
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371710 100 tests £269
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Description

CLEC5A/MDL1 is a 40 kD transmembrane glycoprotein belonging to the C-type lectin superfamily; alternative splice variants have been described but their full-length sequence has not been determined. CLEC5A mediates inflammatory responses during autoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses. It also positively regulates osteoclastogenesis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Partial recombinant protein (28 — 188 a.a.) expressed in 293E cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2910420 (BioLegend Cat. No. 371709)
AB_2910420 (BioLegend Cat. No. 371710)

Antigen Details

Structure
Approximately 21 kD C-type lectin domain-containing glyocoprotein.
Distribution

Expressed on immature myeloid cells, monocytes, macrophages, dendritic cells, neutrophils, NK cells, and osteocytes.

Function
Cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response.
Interaction
DAP12, TYROBP
Ligand/Receptor
Dengue Virus Envelope Proteins
Cell Type
Dendritic cells, Macrophages, Monocytes, Neutrophils, NK cells
Biology Area
Cell Adhesion, Cell Biology, Immunology
Antigen References

1. Chen DY, et al. 2014. PLoS One e86105.
2. Wu MF, et al. 2013. Blood 121:95.
3. Yang YL, et al. 2012. J. Biomed. Biotechnol. 2012:398628.
4. Watson AA, et al. 2011. J. Biol. Chem. 286(27):24208.

Gene ID
23601 View all products for this Gene ID
UniProt
View information about CLEC5A on UniProt.org
Go To Top Version: 1    Revision Date: 02/22/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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