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APC anti-human Delta-like protein 4 (DLL4) Antibody

Pricing & Availability
Clone
MHD4-46 (See other available formats)
Regulatory Status
RUO
Other Names
Delta4, Drosophila Delta homolog 4
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
MHD4-46_APC_051012
Human DLL4-transfected CHO cells were stained with DLL4 (clone MHD4-46) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
  • MHD4-46_APC_051012
    Human DLL4-transfected CHO cells were stained with DLL4 (clone MHD4-46) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
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346507 25 tests £102
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346508 100 tests £240
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Description

Delta-like protein 4 (DLL4) is a type I transmembrane protein whose extracellular domain contains a DSL domain and eight tandem EGF repeats. After binding of its ligands Notch 1 and Notch 4, the extracellular and cytoplasmic domains are cleaved and the cytoplasmic domain is translocated into the nucleus. DLL4 is expressed in the vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes. It is also highly expressed in some types of bladder, breast, and renal carcinomas. DLL4 is critical in vascular development and homeostasis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human DLL4
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications for the relevant formats include: blocking of DLL4 binding to Notch 1 and Notch 4.

Application References

(PubMed link indicates BioLegend citation)
  1. Yamanda S, et al. 2009. Blood 113:3631.
Product Citations
  1. Bagheri V et al. 2018. Journal of cellular physiology. 233(10):7036-7046 . PubMed
  2. Xiong H, et al. 2021. Theranostics. 11:1594. PubMed
RRID
AB_11204421 (BioLegend Cat. No. 346507)
AB_11204421 (BioLegend Cat. No. 346508)

Antigen Details

Structure
Type I transmembrane protein whose extracellular domain contains a DSL domain and eight tandem EGF repeats
Distribution
Vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes; highly expressed in some types of bladder, breast and renal carcinomas
Function
Vascular development and homeostasis
Ligand/Receptor
Notch 1 and Notch 4
Cell Type
Epithelial cells, Endothelial cells, Dendritic cells, Tregs
Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
Adhesion Molecules
Antigen References

1. Beck RC, et al. 2009. Biol Blood Marrow Transplant. 15:1026.
2. Mazella J, et al. 2008. Endocrinology. 149:15.
3. Noguera-Troise I, et al. 2006. Nature 444:1032.
4. Sugimoto A, et al. 2006. Exp Hematol. 34:424.
5. Liu ZJ, et al. 2003. Mol Cell Biol. 23:14.

Gene ID
54567 View all products for this Gene ID
UniProt
View information about DLL4 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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