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APC anti-human IL12RB2 Antibody

Pricing & Availability
Clone
S16020B (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin-12 receptor subunit beta-2
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
S16020B_APC_IL12RB2_Antibody_020122
Human peripheral blood lymphocytes were activated for 3 days with anti-human CD3, anti-human CD28, and recombinant human IL-2 and then stained with anti-human CD25 PE and anti-human IL12RB2 (clone S16020B) (left) APC or mouse IgG2a, κ APC isotype control (right). Cells gated on the anti-human CD3 positive population.
  • S16020B_APC_IL12RB2_Antibody_020122
    Human peripheral blood lymphocytes were activated for 3 days with anti-human CD3, anti-human CD28, and recombinant human IL-2 and then stained with anti-human CD25 PE and anti-human IL12RB2 (clone S16020B) (left) APC or mouse IgG2a, κ APC isotype control (right). Cells gated on the anti-human CD3 positive population.
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394209 25 tests £122
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394210 100 tests £265
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Description

IL12RB2 is a type I transmembrane protein that foms an heterodimer with IL12RB1 to produce the high affinity IL-12 receptor complex. IL12RB2 is expressed by activated T cells, TH1 cells, NK cells, B cells and plasma cells. Variants of this gene are associated with predisposition to various immune-related diseases.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human IL12RB2 transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC – Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2910454 (BioLegend Cat. No. 394209)
AB_2910454 (BioLegend Cat. No. 394210)

Antigen Details

Structure
Type I transmembrane protein, 3 isoforms, foms an heterodimer with IL12RB1
Distribution

Activated T cells, TH1 cells, NK cells, B cells,  plasma cells

Function
Role in TH1 differentiation
Ligand/Receptor
IL-12
Cell Type
B cells, NK cells, Plasma cells, T cells, Th1
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. LaMere SA, et al. 2017. J Immunol. 199:3158
  2. Prigione I, et al. 2016. Immunobiology. 221:291
  3. de Paus RA, et al. 2013. Mol Immunol. 56:380
  4. Airoldi I, et al. 2008. Blood. 112:750
Gene ID
3595 View all products for this Gene ID
UniProt
View information about IL12RB2 on UniProt.org
Go To Top Version: 1    Revision Date: 02/01/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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