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APC anti-mouse/human CD207 (Langerin) Antibody

Pricing & Availability
Clone
4C7 (See other available formats)
Regulatory Status
RUO
Other Names
CLEC4K
Isotype
Mouse IgG2a, κ
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Product Citations
publications
4C7_APC_CD207_Antibody_FC_1_041013
Cells from a collagenase-digested BALB/c mouse spleen were stained with CD11c Alexa Fluor® 488 and CD207 (clone 4C7) APC (top) or mouse IgG2a, κ APC isotype control (bottom).
  • 4C7_APC_CD207_Antibody_FC_1_041013
    Cells from a collagenase-digested BALB/c mouse spleen were stained with CD11c Alexa Fluor® 488 and CD207 (clone 4C7) APC (top) or mouse IgG2a, κ APC isotype control (bottom).
  • 4C7_APC_CD207_Antibody_FC_2_041013
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144205 25 µg £94
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144206 100 µg £240
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Description

CD207, also known as langerin, is a 40 kD single-pass type II transmembrane protein, member of the C-type lectin family. CD207 is expressed on the cell surface and Birbeck granules (BGs) of Langerhans cells, and subsets of thymic and splenic dendritic cells. Its ligands are mannose, n-acetylglucosamine, fucose, and sulfated glycans. Langerin is involved in the antigen processing pathway through capture and internalization of its ligands.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human
Reported Reactivity
Cynomolgus, Rabbit, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Langerin extracellular domain-Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Kawasaki T, et al. 2022. Cell Rep. 41:111828. PubMed
  2. Qiu Z, et al. 2022. J Exp Med. 219:. PubMed
  3. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  4. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  5. Hartwig T et al. 2018. Cell reports. 25(13):3564-3572 . PubMed
  6. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  7. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  8. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
RRID
AB_2561997 (BioLegend Cat. No. 144205)
AB_2561997 (BioLegend Cat. No. 144206)

Antigen Details

Structure
Single-pass type II transmembrane protein, 40 kD, one C-type lectin domain, homotrimer
Distribution

Langerhans cells, subsets of thymic and splenic dendritic cells

Function
Antigen uptake, antigen processing
Ligand/Receptor
Mannose, n-acetylglucosamine, fucose, sulfated glycans
Cell Type
Dendritic cells, Langerhans cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Romani N, et al. 2012. Curr. Top. Microbiol. Immunol. 351:113.
2. Kaplan DH. 2010. Trends Immunol. 31:446.
3. Clausen BE and Kel JM. 2010. Immunol. Cell. Biol. 88:351.
4. Merad M, et al. 2008. Nat. Rev. Immunol. 8:935.

Gene ID
246278 View all products for this Gene ID 50489 View all products for this Gene ID
UniProt
View information about CD207 on UniProt.org
Go To Top Version: 4    Revision Date: 12/08/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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