APC/Cyanine7 anti-human CD159a (NKG2A) Antibody, CD159a, S19004C

Pricing & Availability

Clone: S19004C (See other available formats)
Regulatory Status: RUO
Other Names: Killer Cell Lectin Like Receptor C1, KLRC1, NK Cell Receptor A
Isotype: Mouse IgG1, κ
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Product Citations: publications

S19004C_APC-CYA7_CD159a_Antibody_122723 — Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD159a (NKG2A) (clone S19004C) APC/Cyanine7 (left) or mouse IgG1, κ APC/Cyanine7 isotype control (right).

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375151

25 tests

£121

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375152

100 tests

£293

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Description

CD159a, also known as NKG2A or KLRC1, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2A is an inhibitory NK cell receptor and it is expressed as a heterodimer with CD94. In human, NKG2A/CD94 complex interacts HLA-E on target cells and inhibits T cells and NK cell effector functions. Recent studies showed that NKG2A blockade enhances the anti-tumor effect of NK cell and CD8⁺ T cells.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human NKG2A/CD94-transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Application Notes: Clone S19004C does not cross-react with mouse CD159a.
RRID: AB_3097386 (BioLegend Cat. No. 375151)
AB_3097386 (BioLegend Cat. No. 375152)

Antigen Details

Structure: Type II transmembrane proteins of the C-type lectin superfamily
Distribution: NK cells, NKT cells, T cell subsets
Function: Inhibiting NK cell receptor
Ligand/Receptor: HLA-E
Cell Type: Lymphocytes, NK cells, NKT cells, T cells
Biology Area: Immuno-Oncology, Immunology
Molecular Family: Immune Checkpoint Receptors
Antigen References: Brooks AG, et al. 1999. J Immunol. 162:305-13.

Kaiser BK, et al. 2008. Proc Natl Acad Sci U S A. 105: 6696-701.

Braud VM, et al. 2003. Trends Immunol. 24:162-4.

Kamiya T, et al. 2019. J Clin Invest. 129:2094.

André P, et al. 2018. Cell. 175:1731.
Gene ID: 3821 View all products for this Gene ID
UniProt: View information about CD159a on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD159a Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD159a (NKG2A)	S19004C	FC
PE anti-human CD159a (NKG2A)	S19004C	FC
APC anti-human CD159a (NKG2A) Antibody	S19004C	FC
Pacific Blue™ anti-human CD159a (NKG2A) Antibody	S19004C	FC
PE/Cyanine7 anti-human CD159a (NKG2A) Antibody	S19004C	FC
Alexa Fluor® 647 anti-human CD159a (NKG2A) Antibody	S19004C	FC
PE/Cyanine5 anti-human CD159a (NKG2A)	S19004C	FC
APC/Fire™ 750 anti-human CD159a (NKG2A)	S19004C	FC
Alexa Fluor® 700 anti-human CD159a (NKG2A) Antibody	S19004C	FC
PE/Dazzle™ 594 anti-human CD159a (NKG2A) Antibody	S19004C	FC
Biotin anti-human CD159a (NKG2A) Antibody	S19004C	FC
Alexa Fluor® 488 anti-human CD159a (NKG2A)	S19004C	FC
PerCP/Cyanine5.5 anti-human CD159a (NKG2A)	S19004C	FC
FITC anti-human CD159a (NKG2A)	S19004C	FC
TotalSeq™-C1374 anti-human CD159a (NKG2A)	S19004C	PG
TotalSeq™-D1374 anti-human CD159a (NKG2A)	S19004C	PG
TotalSeq™-A1374 anti-human CD159a (NKG2A)	S19004C	PG
APC/Fire™ 810 anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 421™ anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 605™ anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 785™ anti-human CD159a (NKG2A)	S19004C	FC
TotalSeq™-B1374 anti-human CD159a (NKG2A)	S19004C	PG
PerCP/Fire™ 806 anti-human CD159a (NKG2A)	S19004C	FC
PerCP/Fire™ 780 anti-human CD159a (NKG2A)	S19004C	FC
PE/Fire™ 810 anti-human CD159a (NKG2A)	S19004C	FC
APC/Cyanine7 anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 650™ anti-human CD159a (NKG2A)	S19004C	FC
Spark Red™ 718 anti-human CD159a (NKG2A) (Flexi-Fluor™)	S19004C	FC
Brilliant Violet 711™ anti-human CD159a (NKG2A)	S19004C	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 12/27/2023

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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