- Clone
- M1308A10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Immunoglobulin Heavy Constant Gamma 1
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
410604 | 25 µL | £70 | ||||
410603 | 100 µL | £113 |
IgG Fc is a homodimer that is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc fragment mediates opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation through the binding to Fc receptors such as CD16, CD32, CD64, and the complement factor C1.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant human IgG Fc fusion protein
- Formulation
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested dilution is 1:1000-1:10,000. The optimal dilution should be determined by titration for each individual assay of interest.
25 µl and 100 µl of Direct-Blot™ HRP antibody can be used for approximately 5 and 20 Western blots, respectively, at the recommended concentration/dilution. - Additional Product Notes
-
This product was previously named anti-human IgG Fc Antibody.
- Product Citations
-
- RRID
-
AB_2687208 (BioLegend Cat. No. 410604)
AB_2687208 (BioLegend Cat. No. 410603)
Antigen Details
- Structure
- Predicted molecular weight of approximately 50 kD.
- Function
- Opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation.
- Ligand/Receptor
- CD16, CD32, and CD64.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology
- Antigen References
-
1. Paul, WE. 2003. Fundamental Immunology. Lippincott Williams & Wilkins. Philadelphia.
- Gene ID
- 3500 View all products for this Gene ID
- UniProt
- View information about IgG1 Fc on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All IgG1 Fc Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human IgG1 Fc | M1308A10 | WB |
Direct-Blot™ HRP anti-human IgG1 Fc | M1308A10 | WB |
Customers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human IgG1 Fc
Total protein lysates (15 µg protein) from human serum (lane... -
Direct-Blot™ HRP anti-human IgG1 Fc
Mouse serum (lane 1)and human serum (lane 2) (10µg protein f... Human serum (lane 1) and mouse serum (lane 2) (15 µg protein...
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