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- Regulatory Status
- RUO
- Other Names
- Advanced glycosylation end product-specific receptor
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 449904 | 5 plates | £271 | ||||
Receptor for advanced glycation end products is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface molecules. It can be found in adult lung and skin tissue but low levels are found in other tissue types such as endothelia, cardio myocytes, neutrophils, macrophages, lymphocytes, dendritic cells, and the central nervous system. Due to the multi-ligand nature of RAGE, the receptor is involved in activation of many cell signal pathways such as ERK1/2, p38, SHPK/JNK MAP Kinases, rho GTPases, phosphoinositol-3-kinase (PI3K), and JAK/STAT. It has been found to be involved in pathogenesis and complications that are age related such as diabetes and Alzheimer’s, as well as cellular processes such as inflammation, apoptosis, autophagy, and proliferation.
Product DetailsKit Contents
- Kit Contents
-
- Human RAGE ELISA MAX™ Capture Antibody (200X)
- Human RAGE ELISA MAX™ Detection Antibody (200X)
- Human RAGE Standard
- Avidin-HRP (1,000X)
- Substrate Solution D
- Coating Buffer B (5X)
- Blocking Buffer A (2X)
- Assay Diluent D
- Assay Diluent B (5X)
Product Details
- Verified Reactivity
- Human
- Application
-
ELISA
- As a part of BioLegend's efforts to go green, each new lot of the ELISA MAX™ sets will include a summarized version of its manual. Click here for more information.
- Sensitivity
- 41.28 ± 39.7 pg/mL
- Standard Range
- 78.1 - 5000 pg/mL
- Materials Not Included
-
- Microwell plates: BioLegend Cat. No. 423501 is recommended
- Wash Buffer: BioLegend Cat. No. 421601 is recommended, or PBS + 0.05% Tween-20
- Stop Solution: BioLegend Cat. No. 423001 is recommended, or acid solution, e.g. 2N H2SO4
- Plate Sealers: BioLegend Cat. No. 423601 is recommended
- PBS (Phosphate-Buffered Saline): 8.0 g NaCl, 1.16 g Na2HPO4, 0.2 g KH2PO4, 0.2 g KCl, add deionized water to 1 L; pH to 7.4, 0.2 μm filtered
- Deionized (DI) water
- A microplate reader capable of measuring absorbance at 450 nm
- Adjustable pipettes to measure volumes ranging from 2 μL to 1 mL
- Wash bottle or automated microplate washer
- Log-Log graph paper or software for data analysis
- Tubes to prepare standard dilutions
- Timer
Antigen Details
- Cell Type
- Dendritic cells, Endothelial cells, Lymphocytes, Macrophages, Neutrophils
- Biology Area
- Cell Proliferation and Viability, COVID-19, Signal Transduction
- Molecular Family
- Soluble Receptors
- Gene ID
- NA
- UniProt
- View information about RAGE on UniProt.org
Related FAQs
- Do the ELISA MAX™ Deluxe Sets come with plates?
-
No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.
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