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- Clone
- S21018G (See other available formats)
- Regulatory Status
- RUO
- Other Names
- C3b/C4b receptor, complement receptor type 1 (CR1)
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with anti-human CD20 APC and anti-human CD35 (clone S21018G) FITC (left) or rat IgG2a, κ FITC isotype control (right).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 387403 | 25 tests | £65 | ||||
| 387404 | 100 tests | £141 | ||||
CD35, also known as C3b/C4b receptor, is a9 type I single chain of glycoprotein. Complement Receptor type 1 or CR1. Four molecular weight allotypes (160 kD, 190 kD, 220 kD, and 250 kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays an important role in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
- RRID
-
AB_3068089 (BioLegend Cat. No. 387403)
AB_3068089 (BioLegend Cat. No. 387404)
Antigen Details
- Distribution
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B cells, Dendritic cells, Erythrocytes, Granulocytes, Monocytes, NK cells, T cells
- Function
- Adhesion, mediate phagocytosis, inhibit T-cell proliferation
- Ligand/Receptor
- C3b, iC3, C4b, iC4
- Cell Type
- B cells, Dendritic cells, Erythrocytes, Granulocytes, Monocytes, NK cells, T cells
- Biology Area
- Cell Biology, Complement, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules
- Antigen References
-
- Vorup-Jensen T, et al. 2018. Front Immunol. 9:2716.
- Ogembo J, et al. 2013. Cell Rep. 3:371-85.
- Gene ID
- 1378 View all products for this Gene ID
- UniProt
- View information about CD35 on UniProt.org
Other Formats
View All CD35 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| FITC anti-human CD35 | S21018G | FC |
| Purified anti-human CD35 | S21018G | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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FITC anti-human CD35
Human peripheral blood lymphocytes were stained with anti-hu... -
Purified anti-human CD35
Human peripheral blood lymphocytes were stained with purifie...
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