- Clone
- JOVI.1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell receptor beta constant 1, TRBC1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications

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Human peripheral blood lymphocytes were stained with anti-human CD3 APC and anti-human TCR Cβ1 (clone JOVI.1) FITC (left) or mouse IgG2a, κ FITC isotype control (right).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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383509 | 25 tests | £106 | ||||
383510 | 100 tests | £219 |
The T cell receptor beta chain constant region-1 (TCR Cβ1), also known as TRBC1, is a segment of the TCR beta chain that forms the constant region of the T cell receptor. The rearrangement of TCR genes during T cell development leads to the selection of one of two TCR beta constant regions – C1 or C2. Detection of TRBC1 within a comprehensive T cell panel can be used as evidence of clonality akin to the use of kappa/lambda light chain detection in the diagnosis of plasma cell malignancies.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Transgenic mouse lymphocytes expressing human Vβ3-Cβ1 TCR
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
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Blue Laser (488 nm)
- Application Notes
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Clone JOVI.1 can interfere with the binding of clone IP26 on target cells.
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Application References
(PubMed link indicates BioLegend citation) -
- Viney, J L et al. 1992. Hybridoma. 11:701-13.
- Horna, Pedro et al. 2021. Int J Mol Sci. 22:1817.
- RRID
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AB_2927884 (BioLegend Cat. No. 383509)
AB_2927884 (BioLegend Cat. No. 383510)
Antigen Details
- Structure
- Predicted 20 kD Ig-like protein
- Distribution
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T lymphocytes
- Cell Type
- Leukemia, Lymphocytes, T cells, Thymocytes
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology
- Molecular Family
- TCRs
- Antigen References
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- Minden, M D and T W Mak. 1986. Blood. 68:327-36.
- Davis, M M et al. 1997. Ciba Found Symp. 204:94-100.
- Maciocia, Paul M et al. 2017. Nat Med. 23:1416-23.
- Gene ID
- 28639 View all products for this Gene ID
- UniProt
- View information about TCR Cbeta1 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All TCR Cβ1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human TCR Cβ1 | JOVI.1 | FC |
APC anti-human TCR Cβ1 | JOVI.1 | FC |
PE anti-human TCR Cβ1 | JOVI.1 | FC |
PerCP/Cyanine5.5 anti-human TCR Cβ1 | JOVI.1 | FC |
FITC anti-human TCR Cβ1 | JOVI.1 | FC |
Biotin anti-human TCR Cβ1 | JOVI.1 | FC |
Spark Blue™ 550 anti-human TCR Cβ1 (Flexi-Fluor™) | JOVI.1 | FC |
Spark Blue™ 574 anti-human TCR Cβ1 (Flexi-Fluor™) | JOVI.1 | FC |
Spark Violet™ 538 anti-human TCR Cβ1 Antibody | JOVI.1 | FC |
PE/Cyanine7 anti-human TCR Cβ1 Antibody | JOVI.1 | FC |
APC/Fire™ 750 anti-human TCR Cβ1 Antibody | JOVI.1 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with purifie... -
APC anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
PerCP/Cyanine5.5 anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
FITC anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
Biotin anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
Spark Blue™ 550 anti-human TCR Cβ1 (Flexi-Fluor™)
-
Spark Blue™ 574 anti-human TCR Cβ1 (Flexi-Fluor™)
-
Spark Violet™ 538 anti-human TCR Cβ1 Antibody
Human peripheral blood lymphocytes were stained with anti-hu... -
PE/Cyanine7 anti-human TCR Cβ1 Antibody
Human peripheral blood lymphocytes were stained with anti-hu... -
APC/Fire™ 750 anti-human TCR Cβ1 Antibody
Human peripheral blood lymphocytes were stained with anti-hu...
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