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FITC anti-mouse TCR Vβ7 Antibody

Pricing & Availability
Clone
TR310 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor Vβ7 chain
Isotype
Rat IgG2b, κ
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Product Citations
publications
TR310_FITC_021808
Balb/c mouse splenocytes stained with CD3 (145-2C11) APC and TR310 FITC
  • TR310_FITC_021808
    Balb/c mouse splenocytes stained with CD3 (145-2C11) APC and TR310 FITC
See FITC spectral data
Cat # Size Price Quantity Check Availability Save
118305 50 µg £65
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118306 200 µg £141
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Description

The TR310 antibody reacts with the mouse T cell receptor Vβ7 segment . T cells expressing the α/β T cell receptor use clonally distributed TCRs to recognize cell-bound antigens such as peptide/MHC complexes and viral superantigens. The α/β TCR is an oligomeric TCR complex composed of covalently bound α and β chains involved in antigen recognition and the non-covalently associated monomorphic proteins CD3δ, γ, ε, and ζ chains. The TR310 antibody reacts with one such clonally distributed TCR β chain known as Vβ7. Vβ7 is expressed on a small subpopulation of both CD4+ and CD8+ T cells. The TR310 antibody has been used for the identification of Vβ7 expressing T cells by flow cytometry and immunoprecipitation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
T cell lymphoma TK-1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Additional reported applications (for the relevant formats) include immunoprecipitation2.

Application References

(PubMed link indicates BioLegend citation)
  1. Ito K, et al. 2000. Proc. Natl. Sci. USA 97:740.
  2. Okada CY, et al. 1990. J. Immunol. 144:3473.
RRID
AB_893630 (BioLegend Cat. No. 118305)
AB_893630 (BioLegend Cat. No. 118306)

Antigen Details

Structure
Ig superfamily member, TCR α/β with CD3 forms the CD3/TCR complex
Distribution

Expressed on a subpopulation of CD4+ and CD8+ T cells bearing the Vβ7 T cell receptor segment

Function
Antigen recognition, T cell activation
Ligand/Receptor
Peptide bound to MHC
Receptors
Peptide bound to MHC
Cell Type
T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
TCRs
Antigen References

1. Okada CY, et al. 1990. J. Immunol. 144:3473.

Gene ID
21577 View all products for this Gene ID
UniProt
View information about TCR Vbeta7 on UniProt.org
Go To Top Version: 2    Revision Date: 09/01/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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