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Pacific Blue™ anti-mouse CD38 Antibody

Pricing & Availability
Clone
90 (See other available formats)
Regulatory Status
RUO
Other Names
T10
Isotype
Rat IgG2a, κ
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Product Citations
publications
90_PB_040810
C57BL/6 mouse splenocytes stained with 90 Pacific Blue™
  • 90_PB_040810
    C57BL/6 mouse splenocytes stained with 90 Pacific Blue™
Compare all formats See Pacific Blue™ spectral data
Cat # Size Price Quantity Check Availability Save
102719 25 µg £70
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102720 100 µg £165
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow pre-B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume or 100 µl of whole blood.  It is recommended that the reagent be titrated for optimal performance for each application.

* Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

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Excitation Laser
Violet Laser (405 nm)
Product Citations
  1. Chen Q, et al. 2022. Cell Rep. 39:110990. PubMed
  2. Schaefer-Babajew D, et al. 2023. Nature. 613:735. PubMed
  3. Hägglöf T, et al. 2023. Cell. 186:147. PubMed
  4. Kodali S, et al. 2022. J Immunol. 208:1085. PubMed
  5. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  6. Onodera T, et al. 2019. J Immunol. 203:3282. PubMed
  7. Chen M, et al. 2016. J Immunol . 194: 2607-15. PubMed
  8. Viant C, et al. 2021. J Exp Med. 218:. PubMed
  9. Wang JC, et al. 2022. Elife. 11:. PubMed
  10. Ma K, et al. 2022. iScience. 25:104347. PubMed
  11. Yang P et al. 2019. Cell Syst. 8(5):427-445 . PubMed
  12. Ghosh D, et al. 2016. J Immunol. 197: 1788 - 1800. PubMed
  13. Adachi Y, et al. 2019. Nat Commun. 10:3883. PubMed
  14. Lutz J, et al. 2015. Nat Commun. 6: 8575. PubMed
  15. Viant C, et al. 2020. Cell. 183:1298. PubMed
  16. Adachi Y, et al. 2015. J Exp Med. 212: 1709-1723. PubMed
  17. Viant C, et al. 2021. STAR Protocols. 2(2):100389. PubMed
  18. Jang A, et al. 2021. Front Immunol. 12:701066. PubMed
RRID
AB_10613289 (BioLegend Cat. No. 102719)
AB_10613289 (BioLegend Cat. No. 102720)

Antigen Details

Structure
ADP-ribosyl hydrolase, 42 kD
Distribution

B cells, NK cells, T cell subset, brain, muscle, kidney

Function
Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor
CD31, hyaluronic acid
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Shubinsky G, et al. 1997. Immunity 7:315.
3. Cesano A, et al. 1998. J. Immunol. 160:1106.
4. Cockayne DA, et al. 1998. Blood 92:1324.

Gene ID
12494 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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