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PE anti-human CD158f (KIR2DL5) Antibody

Pricing & Availability
Clone
UP-R1 (See other available formats)
Regulatory Status
RUO
Other Names
KIR2DL5
Isotype
Mouse IgG1, κ
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Product Citations
publications
UP-R1_PE_042909.jpg
Human peripheral blood lymphocytes stained with UP-R1 PE and CD56 (HCD56) APC
  • UP-R1_PE_042909.jpg
    Human peripheral blood lymphocytes stained with UP-R1 PE and CD56 (HCD56) APC
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Cat # Size Price Quantity Check Availability Save
341303 25 tests £105
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341304 100 tests £242
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Description

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 14 polymorphic KIR genes have been reported in humans. CD158f is a 60 kD glycoprotein with 2 Ig-like extracellular domains and long cytoplasmic domains. Its expression is highly polymorphic between individuals and mainly expressed on a subset of NK cells and a small population of T cells. HLA class I alleles are the ligands of CD158f.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human KIR2DL5-Ig fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Estefania E, et al. 2007. J. Immunol. 178:4402
Product Citations
  1. Holder KA, et al. 2021. Clin Transl Immunology. 10:e1348. PubMed
  2. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  3. Mou SQ, et al. 2021. Front Pharmacol. 12:648688. PubMed
  4. Cisneros E, et al. 2017. Front Immunol. 0.776388889. PubMed
  5. Samarani S, et al. 2020. Mediators Inflamm. 2020:6401969. PubMed
RRID
AB_2130701 (BioLegend Cat. No. 341303)
AB_2130701 (BioLegend Cat. No. 341304)

Antigen Details

Structure
Contains two Ig-like extracellular domains, 60 kD
Distribution

Subset of NK cells and a small subset of T cells, polymorphic expression

Function
Inhibits NK cell function, play a role in self-tolerance.
Ligand/Receptor
HLA alleles
Cell Type
NK cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Gonzalez A, et al. 2008. Tissue Antigens. 72:11

Gene ID
57292 View all products for this Gene ID
UniProt
View information about CD158f on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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