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PE anti-human CD179a (VpreB) Antibody

Pricing & Availability
Clone
HSL96 (See other available formats)
Regulatory Status
RUO
Other Names
VpreB, VPREB1, IGVPB
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HSL96_PE_021610
Human pre-B cell line NALM6 stained with HSL96 PE
  • HSL96_PE_021610
    Human pre-B cell line NALM6 stained with HSL96 PE
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347404 100 tests £234
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Description

CD179a is an 18 kD Ig V-like protein expressed on pro-B and early pre-B cells. It is a member of the Ig gene superfamily, known as VpreB, VPREB1, and IGVPB. CD179a noncovalently associates with CD179b (λ5) to form a surrogate light (SL) chain. The SL chain is complexed with membrane bound IgM heavy (µH) chain and CD79a/CD79b heterodimer to form the pre-B-cell receptor (PreBCR) complex. The function of CD179a/CD179b is still under investigation though it has been reported that the pre-BCR complex plays a critical role in B cell development.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Tsyganezawa K, et al. 1998. Blood 92:4317
  2. Kiyokawa N, et al. 2004. Modern Pathology. 17:423
Product Citations
  1. Kraus H, et al. 2014. J Immunol. 192:1044. PubMed
  2. Köhrer S, et al. 2016. Leukemia. 10.1038/leu.2016.9. PubMed
RRID
AB_2216935 (BioLegend Cat. No. 347404)

Antigen Details

Structure
Ig superfamily, Ig V-like, 18 kD, noncovalently associates with CD179b to form surrogate light (SL) chain
Distribution

Pro-B and early Pre-B cells

Cell Type
B cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication
2. Zhang M, et al. 2004. Cell. Mol. Immunol. 1:89

Gene ID
7441 View all products for this Gene ID
UniProt
View information about CD179a on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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