PE anti-human CD44 isoform 9 CD44v9 Antibody, CD44, RV3

Pricing & Availability

Clone: RV3 (See other available formats)
Regulatory Status: RUO
Other Names: CD44 variant 9, CD44 variant isoform 9
Isotype: Rat IgG2a, κ
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Product Citations: publications

PHA-stimulated (3 days) human peripheral blood lymphocytes were stained with CD44 isoform 9 (CD44v9) (clone RV3) PE (filled histogram) or Rat IgG2a, κ isotype control PE (open histogram).

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394403

25 tests

£81

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394404

100 tests

£192

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Description

CD44 isoform 9, also known as CD44v9, is a CD44 isofom consisting of exons 1-5, 13 (v9) and 15 to 19, product of alternative splicing. CD44v9 is expressed by cancer stem cells, epithelial-type carcinomas, subsets of monocytes and subsets of lymphocytes; have a role in tumor initiation, maintenance and metastasis of cancer cells. CD44v9 interacts with the glutamate-cystine transporter xCT, increasing reduced glutathione and contributing to the ROS resistance of cancer cells, and is a potential predictive marker for recurrence of some cancers and a potential therapeutic target.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Human CD44v8-10 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue sections³.
RRID: AB_2814344 (BioLegend Cat. No. 394403)
AB_2814344 (BioLegend Cat. No. 394404)

Antigen Details

Distribution: Cancer stem cells, epithelial-type carcinomas, subset of monocytes, subset of lymphocytes.
Function: Role in tumor initiation and maintenance and metastasis of cancer cells, Interacts with the glutamate-cystine transporter xCT, increasing reduced glutathione and contributing to the ROS resistance of cancer cells.
Cell Type: Epithelial cells, Lymphocytes, Monocytes, Neutrophils
Biology Area: Cancer Biomarkers, Cell Biology, Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Hagiwara M, et al. 2018. BMC Cancer. 18:113

Matsumoto T, et al. 2017. Oncogenesis. 6:397

Bertaux-Skeirik N, et al. 2017. J. Pathol. 242:463

Kodama H, et al. 2017. Br. J. Cancer. 116:186
Gene ID: 960 View all products for this Gene ID
UniProt: View information about CD44v9 on UniProt.org

Documentation

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Description	Clone	Applications

Related Pages & Pathways

Pathways

Related FAQs

What type of PE do you use in your conjugates?: We use R-PE in our conjugates.

Other Formats

View All CD44v9 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD44 variant 9 (CD44v9)	RV3	FC,IHC-P,IHC-F
Alexa Fluor® 594 anti-human CD44 variant 9 (CD44v9)	RV3	IHC-P
PE anti-human CD44 variant 9 (CD44v9)	RV3	FC
Alexa Fluor® 647 anti-human CD44 variant 9 (CD44v9)	RV3	FC,IHC-P

Certificate of Analysis

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Go To Top Version: 2 Revision Date: 02/22/2023

For Research Use Only. Not for diagnostic or therapeutic use.

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