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PE anti-human GPR56 Antibody

Pricing & Availability
Clone
CG4 (See other available formats)
Regulatory Status
RUO
Other Names
TM7XN1
Isotype
Mouse IgG1, κ
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Product Citations
publications
CG4_PE_GPR56_Antibody_FC_1_051413
Human peripheral blood lymphocytes were stained with CD56 APC and GPR56 (clone CG4) PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • CG4_PE_GPR56_Antibody_FC_1_051413
    Human peripheral blood lymphocytes were stained with CD56 APC and GPR56 (clone CG4) PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • CG4_PE_GPR56_Antibody_FC_2_051413
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358203 25 tests £92
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358204 100 tests £215
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Description

GPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids.  GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8+, CD4+, and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human GPR56-mouse Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone CG4 cross-reacts with mouse1.

Application References

(PubMed link indicates BioLegend citation)
  1. Rao TN, et al. 2015. Stem Cell Res. 14:307. (FC) PubMed
Product Citations
  1. Houtsma R, et al. 2021. STAR Protoc. 2:100864. PubMed
  2. Pabst C, et al. 2016. Blood. 127: 2018-2027. PubMed
  3. Yeo L, et al. 2018. J Clin Invest. 128:3460. PubMed
  4. He L, et al. 2022. EMBO Mol Med. 14:e14990. PubMed
  5. Tomellini E, et al. 2020. Cell Reports. 28(4):1063-1073.e5.. PubMed
  6. Pais H, et al. 2019. Sci Rep. 9:5760. PubMed
RRID
AB_2562084 (BioLegend Cat. No. 358203)
AB_2562084 (BioLegend Cat. No. 358204)

Antigen Details

Structure
Contains seven transmembrane domains and a mucin-like domain in the N-terminal region
Distribution

T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart

Function
May be involved in immune cell migration, cancer cell growth metastasis, and neuron development
Cell Type
NK cells, T cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules
Antigen References

1. Peng YM, et al. 2011. J. Leukoc. Biol. 90:735.
2. Shashidhar S, et al. 2005. Oncogene 24:1673.
3. Piao X, et al. 2004. Science 303:2033.
4. Liu M, et al. 1999. Genomics 55:296.

Gene ID
9289 View all products for this Gene ID
UniProt
View information about GPR56 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 12/02/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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