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PE anti-human GPR83 Antibody

Pricing & Availability
Clone
K07JP05 (See other available formats)
Regulatory Status
RUO
Other Names
G Protein-Coupled Receptor 83, GIR, Glucocorticoid Induced Receptor, GPR72, G Protein-Couple Receptor 72, KIA1540, JP05
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
K07JP05_PE_GRP83_Antibody_Antibody_FC_121114
GPR83 transfected CHO-K1 cells were stained with anti-human GPR83 (clone K07JP05) PE (filled histogram) or PE mouse IgG2a, κ isotype control (open histogram).
  • K07JP05_PE_GRP83_Antibody_Antibody_FC_121114
    GPR83 transfected CHO-K1 cells were stained with anti-human GPR83 (clone K07JP05) PE (filled histogram) or PE mouse IgG2a, κ isotype control (open histogram).
See PE spectral data
Cat # Size Price Quantity Check Availability Save
363305 25 tests £105
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363306 100 tests £215
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Description

GPR83, also known as GIR, is a seven-pass membrane protein that belongs to the G-protein coupled receptor 1 family. GPR83 is an orphan GPR homologous to tachykinin and neuropeptide Y (NPY) receptors. GPR83 is expressed in the brain and in both murine and human Treg cells. GPR83 is reported to regulate core body temperature and there are four isoforms of GPR83. Studies have suggested that isoform-4, but not isoform-1, is associated with the suppressive functions of Treg cells. The precise role of GPR83 in Treg function is unclear.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
DNA vaccine with full coding sequence of human GPCR cloned in expression vector.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2564580 (BioLegend Cat. No. 363305)
AB_2564580 (BioLegend Cat. No. 363306)

Antigen Details

Structure
Orphan GPR, homologous to tachykinin and neuropeptide Y (NPY) receptors. Belongs to the G-protein coupled receptor 1 family and is approximately 48 kD.
Distribution
Found on neurons in the brain and Tregs.
Function
Induces Foxp3 expression in CD4+ T cells, and may be involved in thermoregulation.
Interaction
Forms a heterodimer with Ghsr1a or homodimerizes.
Cell Type
Neurons, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. De Moerlooze L, et al. 2000. Cytogenet. Cell Genet. 90:146.
2. Hansen W, et al. 2006. J. Immunol. 177:209.
3. Sugimoto N et al. 2006. Int. Immunol. 18:1197.
4. Lu LF, et al. 2007. Mol. Cell Biol. 27: 8065.
5. Müller TD, et al. 2013. Nat. Commun. 4:1968. 

Gene ID
10888 View all products for this Gene ID
UniProt
View information about GPR83 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 12/16/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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