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PE anti-human TLT-2 Antibody

Pricing & Availability
Clone
MIH60 (See other available formats)
Regulatory Status
RUO
Other Names
TREML2
Isotype
Mouse IgG2b, κ
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Product Citations
publications
MIH60_PE_1_033111
Human peripheral blood lymphocytes were stained with CD19 APC and TLT2 (clone MIH60) PE (middle) or mouse IgG2b isotype control (bottom).
  • MIH60_PE_1_033111
    Human peripheral blood lymphocytes were stained with CD19 APC and TLT2 (clone MIH60) PE (middle) or mouse IgG2b isotype control (bottom).
  • MIH60_PE_2_033111
    Human peripheral blood granulocytes were stained with TLT2 (clone MIH60) PE (filled histogram) or mouse IgG2b PE isotype control (open histogram).
  • MIH60_PE_3_033111
See PE spectral data
Cat # Size Price Quantity Check Availability Save
351204 100 tests £217
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Description

Trem-like transcript 2 protein (TLT2), also known as TREML2, is a 33 kD (unglycosylated) type I transmembrane protein with a single IgV domain contains two potential N-glycosylation sites, a serine/threonine-rich region with numerous predicted O-linked glycosylation sites, a single membrane-spanning region, and a short cytoplasmic tail. TLT2 is expressed on B lineage cells, macrophages, neutrophils in bone marrow and periphery, and the expression level can be upregulated in response to inflammation. As a receptor, TLT2 likely plays a role in innate immunity. Recent studies have demonstrated that ligation of TLT2 inhibits the oxidative burst in neutrophils upon fMLP stimulation, indicating that TLT2 may function as an inhibitory receptor that attenuates activation of neutrophils, and possibly macrophages. Recently TLT-2 protein has been found on CD8+ T cells and is induced on activated CD4+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human TLT-2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_10900239 (BioLegend Cat. No. 351204)

Antigen Details

Structure
Type I transmembrane protein with IgV type domain and one potential site of N linked glycosylation at extracellular domain
Distribution
B cell, macrophages, neutrophils
Function
Inhibitory receptor
Interaction
B7H3
Cell Type
B cells, Macrophages, Neutrophils
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Antigen References

1. Ford JW, et al. 2009. Curr. Opin. Immunol. 21:38.
2. Hashiguchi M, et al. 2008. P. Natl. Acad. Sci. USA 105:10495.
3. King RG, et al. 2006. J. Immunol. 176:6012.
4. Leitner J, et al. 2009. Eur. J. Immunol. 39:1754.
5. Park-Min KH, et al. 2009. J. Immunol. 183:2444.
6. Hashiguchi M, et al. 2008. P. Natl. Acad. Sci. USA 105:10495.

Gene ID
79865 View all products for this Gene ID
UniProt
View information about TLT-2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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