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PE anti-mouse CD155 (PVR) Antibody

Pricing & Availability
Clone
4.24.1 (See other available formats)
Regulatory Status
RUO
Other Names
PVR (poliovirus receptor) homolog
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
4dot24dot1_PE_011409.jpg
C57BL/6 splenocytes stained with RA3-6B2 (B220) APC and 4.24.1 PE
  • 4dot24dot1_PE_011409.jpg
    C57BL/6 splenocytes stained with RA3-6B2 (B220) APC and 4.24.1 PE
See PE spectral data
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132205 25 µg £97
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132206 100 µg £234
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Description

Mouse CD155, also known as homolog of polivirus receptor, is the founding member of a subfamily of immunoglobulin-like adhesion receptors (nectins). Mouse CD155 is expressed on a wide variety of cells of hematopoietic origin apart from its existence on the epithelial cells. The engagement of CD155 with CD226 and CD96 induces cytotoxicity of NK cells and CTL.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
EL4 transfected with mouse CD155
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Tahara-Hanaoka S, et al. 2004. Int Immunol 16:533
  2. Maier MK, et al. 2007. Eur J. Immunol. 37:2214
  3. Bottino C, et al. 2003. J. Exp. Med. 198:557
  4. Chan CJ, et al. 2010. J. Immunol. 184;902. PubMed
Product Citations
  1. Lin C, et al. 2020. Cancer Immunol Res. 632:8. PubMed
  2. Briukhovetska D, et al. 2023. Immunity. 56:143. PubMed
  3. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  4. Chan C, et al. 2010. J Immunol. 184:902. PubMed
  5. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  6. Shaashua L, et al. 2022. Nat Commun. 13:6513. PubMed
RRID
AB_1279103 (BioLegend Cat. No. 132205)
AB_1279103 (BioLegend Cat. No. 132206)

Antigen Details

Structure
70 kd immunoglobulin-like molecule with three Ig-like domains.
Distribution

CD155 is expressed at cell junctions on the primary vascular endothelial cells. Moreover, mouse CD155 is highly expressed on DP thymocytes and expression level is dropped in peripheral single positive CD4+ and CD8+ T cells. CD155 can be detected on T reg, other activated T cells and on NKT cells. Resident monocytes express moderate amount of CD155, but upregulated its expression during inflammation. Other cells, such as IEL, neutrophils and subsets of B cells were found to express CD155 to varying extents.

Function
Apart from its function of adhering junction among contacting epithelial cells, the interaction of DNAM-1 (CD226) with its ligands CD155 and CD112 (nectin 2) induces cytotoxcity of NK cells and CD8+ T cells and cytokine secretion.
Ligand/Receptor
CD226 (DNAM-1), CD96
Cell Type
B cells, Monocytes, Neutrophils, T cells, Thymocytes, Tregs
Biology Area
Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Mendelsohn C et al. 1989. Cell 56:855

Gene ID
52118 View all products for this Gene ID
UniProt
View information about CD155 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 07/28/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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