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PE anti-mouse CD193 (CCR3) Antibody

Pricing & Availability
Clone
J073E5 (See other available formats)
Regulatory Status
RUO
Other Names
CC CKR3, MIP1-α receptor like-2, eotaxin receptor, MIP1-alpha receptor like-2
Isotype
Rat IgG2a, κ
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Product Citations
publications
J073E5_PE_CD193_Antibody_FC_1_051313
C57BL/6 mouse peripheral blood myeloid cells were stained with Gr-1 APC and CD193 (clone J073E5) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • J073E5_PE_CD193_Antibody_FC_1_051313
    C57BL/6 mouse peripheral blood myeloid cells were stained with Gr-1 APC and CD193 (clone J073E5) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • J073E5_PE_CD193_Antibody_FC_2_051313
Compare all formats See PE spectral data
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144505 25 µg £109
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144506 100 µg £230
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Description

CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-α receptor like-2, and eotaxin receptor, is a member of the G protein-coupled, seven transmembrane receptor family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CD193 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CD193 is expressed on mouse eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, hematopoietic progenitor cells, and keratinocytes. It is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CD193 also function as a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CD193 has been shown to inhibit HIV infection in some cell types.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CCR3-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Bao H, et al. 2020. Mol Med Rep. 4.675. PubMed
  2. Wiesner D, et al. 2016. J Immunol. 196: 365 - 374. PubMed
  3. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  4. Kline JM, et al. 2021. J Biol Chem. :100373. PubMed
  5. Gicheva N, et al. 2016. Biochem Biophys Res Commun. 479:1-4. PubMed
  6. Verma M, et al. 2021. J Exp Med. 218:. PubMed
  7. Spath S, et al. 2022. iScience. 25:104998. PubMed
  8. Fend L, et al. 2014. Cancer Immunol Res. 2:1163. PubMed
  9. Ehrens A, et al. 2021. Cell Reports. 34(2):108621. PubMed
RRID
AB_2561533 (BioLegend Cat. No. 144505)
AB_2561533 (BioLegend Cat. No. 144506)

Antigen Details

Structure
G-protein coupled, seven transmembrane domain receptor, 356 amino acids
Distribution

Eosinophils, basophils, mast, mononuclear phagocytes, platelets, hematopoietic progenitor, keratinocytes

Function
Co-receptor for HIV-1 and HIV-2, allergy
Ligand/Receptor
Eotaxin, eotaxin-2, eotaxin-3, RANTES, MCP-3, and MCP-4
Cell Type
Basophils, Eosinophils, Hematopoietic stem and progenitors, Mast cells, Platelets
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Zlotnik A, et al. 2006. Genome Biol. 7:243.
2. Kodali RB, et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24:1211.
3. Das AM, et al. 2006. J. Pharmacol. Exp. Ther. 318:411.
4. Huaux F, et al. 2005. Am. J. Pathol. 167:1485.
5. Puxeddu I, et al. 2006. J. Allergy Clin. Immunol. 117:103.

Gene ID
12771 View all products for this Gene ID
UniProt
View information about CD193 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?

Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.

Go To Top Version: 2    Revision Date: 05/13/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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