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PE anti-mouse CD39 Antibody

Pricing & Availability
Clone
Duha59 (See other available formats)
Regulatory Status
RUO
Other Names
Entpd1, NTPDase1
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
Duha59_PE_1_050812
C57BL/6 mouse lymph node cells were stained with CD4 PerCP, CD25 APC, and CD39 (clone Duha59) PE (top) or rat IgG2a, κ PE isotype control (bottom). The data was analyzed by gating on CD4+ cells.
  • Duha59_PE_1_050812
    C57BL/6 mouse lymph node cells were stained with CD4 PerCP, CD25 APC, and CD39 (clone Duha59) PE (top) or rat IgG2a, κ PE isotype control (bottom). The data was analyzed by gating on CD4+ cells.
  • Duha59_PE_2_050812
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Cat # Size Price Quantity Check Availability Save
143803 25 µg £84
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143804 100 µg £184
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Description

CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of the ectonucleoside triphosphate dihydrolases (E-NTPDases), which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system, and is involved in suppression of inflammation and control of platelet activation. CD39 is expressed on B cells, dendritic cells, and a subset of T cells, including regulatory T cells and memory T cells. The coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
CD39 cDNA expression vector
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  2. Que W, et al. 2022. Sci Adv. 8:eabo4413. PubMed
  3. van Elsas MJ, et al. 2023. J Immunother Cancer. 11:. PubMed
  4. Hu J, et al. 2022. J Immunother Cancer. 10:. PubMed
  5. Zhan Y, et al. 2021. JCI Insight. 6:. PubMed
  6. Zhou Y, et al. 2020. Immunity. 52(2):357-373. PubMed
  7. Colpitts SL, et al. 2017. Gut Microbes. 8:561. PubMed
  8. Emmerson A, et al. 2018. J Clin Invest. 128:3088. PubMed
  9. Becher J, et al. 2018. Dev Cell. 47:592. PubMed
  10. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  11. Hu J, et al. 2022. J Immunother Cancer. 10:. PubMed
  12. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  13. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  14. Katsuyama T, et al. 2021. Cell Reports. 36(1):109339. PubMed
RRID
AB_11219591 (BioLegend Cat. No. 143803)
AB_11219591 (BioLegend Cat. No. 143804)

Antigen Details

Structure
A member of ectonucleoside triphosphate dihydrolases (E-NTPDases), an ectoenzyme that degrades ATP to AMP
Distribution

B cells, dendritic cells, and a subset of T cells

Function
Involved in suppression of inflammation and control of platelet activation; coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops
Interaction
Proteolysis of amyloid precursor protein (APP)
Cell Type
B cells, Dendritic cells, T cells, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Borsellino G, et al. 2007. Blood 110:1225.
2. Deaglio S, et al. 2007. J. Exp. Med. 204:1257.
3. Bynoe MS, et al. 2008. Trends Immunol. 29:99.
4. Ndhlovu LC, et al. 2010. Eur. J. Immunol. 40:134.

Gene ID
12495 View all products for this Gene ID
UniProt
View information about CD39 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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