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- Clone
- mDcR1-3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TNFRH1, mSOB, Tumor necrosis factor receptor superfamily member 23, Tnfrsf23, Tumor necrosis factor receptor p60 homolog 1, TNF receptor family member SOB, Decoy TRAIL receptor 1, TNF receptor homolog 1
- Isotype
- Armenian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Mouse macrophage cell line RAW stained with mDcR1-3 PE
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 133804 | 100 µg | £221 | ||||
Mouse Decoy Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor 1 (mDcTRAIL R1) is a GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain. It expresses on many cell types, including some tumor cells. mDcTRAIL R1 appears to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcR1 in apoptosis has not yet been clarified.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- mDcTRAIL-R1-Fc
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Bareiss PM, et al. 2013. Cancer Res. 73:5544. PubMed
- Product Citations
-
- RRID
-
AB_1626110 (BioLegend Cat. No. 133804)
Antigen Details
- Structure
- GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain.
- Distribution
-
Express on many types of cells, including some tumor cells.
- Function
- Appear to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcR1 in apoptosis has not yet been clarified.
- Ligand/Receptor
- TRAIL
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
1. Yagyu S, et al. 2008. Clin Cancer Res. 14 (21):7011
2. Ashkenazi A, et al. 1998. Science 281:1305 - Gene ID
- 79201 View all products for this Gene ID
- UniProt
- View information about DcTRAIL-R1 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All DcTRAIL-R1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse DcTRAIL-R1 | mDcR1-3 | FC |
Customers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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PE anti-mouse DcTRAIL-R1
Mouse macrophage cell line RAW stained with mDcR1-3 PE
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