Loading...

PE anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
BM8_PE_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
  • BM8_PE_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
123109 25 µg £30
Check Availability


Need larger quantities of this item?
Request Bulk Quote
123110 100 µg £97
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Hasan Z, et al. 2013. Am J Physiol Lung Cell Mol Physiol. 304:221. PubMed
  2. Lee T, et al. 2014. Mol Biol Cell. 25:583. PubMed
  3. Peterson T, et al. 2016. Proc Natl Acad Sci U S A. 113: 4470-4475. PubMed
  4. Wang L, et al. 2020. Front Cell Dev Biol. 0.745138889. PubMed
  5. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  6. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  7. Tan T, et al. 2019. Nat Commun. 10:3322. PubMed
  8. Man SM et al. 2016. Cell. 167(2):382-396 . PubMed
  9. Zhao Y, et al. 2019. Mucosal Immunol. 1.298611111. PubMed
  10. Wang Q, et al. 2019. FASEB Bioadv. 1:609. PubMed
  11. Gordan S, et al. 2020. Cell Reports. 29(10):3033-3046.e4.. PubMed
  12. Wang L, et al. 2021. J Nanobiotechnology. 19:56. PubMed
  13. Chen G, et al. 2021. J Mol Cell Cardiol. 159:62. PubMed
  14. Qin YY, et al. 2022. Mol Ther. 30:881. PubMed
  15. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  16. Zhou Y, et al. 2022. Br J Pharmacol. 179:1978. PubMed
  17. Zhang D, et al. 2022. Cell Stem Cell. 29:232. PubMed
  18. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  19. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  20. van Dierendonck XAMH, et al. 2022. Proc Natl Acad Sci U S A. 119:e2114739119. PubMed
  21. Helfen A, et al. 2022. Neoplasia. 28:100792. PubMed
  22. Pan L, et al. 2022. Mol Immunol. 147:101. PubMed
  23. Chae CS, et al. 2022. Cancer Discov. 12:1904. PubMed
  24. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  25. Campisi L, et al. 2022. Nature. 606:945. PubMed
  26. Gupta S, et al. 2022. Sci Adv. 8:eabn4886. PubMed
  27. Mendivil-Perez M, et al. 2022. Med Oncol. 40:15. PubMed
  28. Liu M, et al. 2022. Cells. 11: . PubMed
  29. Wang Y, et al. 2022. Cell Rep. 41:111738. PubMed
  30. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  31. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  32. García-García A, et al. 2023. Bioact Mater. 24:174. PubMed
  33. Glaubitz J, et al. 2023. Gut. :. PubMed
  34. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  35. Zhang K, et al. 2023. Nat Metab. 5:129. PubMed
  36. Wang D, et al. 2023. J Exp Clin Cancer Res. 42:26. PubMed
  37. Hattori Y, et al. 2023. Cell Rep. 42:112092. PubMed
  38. Yeh CH, et al. 2022. Immunity. 55:272. PubMed
  39. Ye B, et al. 2022. Cell Mol Immunol. 19:619. PubMed
  40. Meacham CE, et al. 2022. Nat Cell Biol. 24:697. PubMed
  41. Morris CR, et al. 2022. Mucosal Immunol. 15:977. PubMed
  42. Sia ZR, et al. 2022. J Virol. 96:e0100622. PubMed
  43. Barsheshet Y, et al. 2022. Int J Mol Sci. 23:. PubMed
  44. Huang Q, et al. 2023. Immun Inflamm Dis. 11:e779. PubMed
  45. Li L, et al. 2023. iScience. 26:106095. PubMed
  46. Zhang X, et al. 2023. Heliyon. 9:e13490. PubMed
  47. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  48. Barberio AE, et al. 2023. Bioeng Transl Med. 8:e10453. PubMed
  49. Gupta T, et al. 2023. Front Immunol. 14:1044703. PubMed
  50. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  51. Han S, et al. 2023. Int J Mol Sci. 24:. PubMed
  52. Thai LM, et al. 2023. iScience. 26:106477. PubMed
  53. Chen S, et al. 2023. J Immunother Cancer. 11:. PubMed
  54. Duan JL, et al. 2023. Nat Aging. 3:258. PubMed
  55. Kaur N, et al. 2023. Heliyon. 9:e14952. PubMed
  56. Yang Y, et al. 2023. Diagnostics (Basel). 13:. PubMed
  57. Tang M, et al. 2023. Sci Adv. 9:eade6624. PubMed
  58. Pathak JL, et al. 2021. Front Cell Dev Biol. 628139:9. PubMed
  59. Huang J, et al. 2021. Immunity. 54(4):673-686.e4. PubMed
  60. Kaczanowska S, et al. 2021. Cell. 184(8):2033-2052.e21. PubMed
  61. Karki R, et al. 2016. Nature. 10.1038/nature20597. PubMed
  62. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  63. Kloepper J, et al. 2016. Proc Natl Acad Sci U S A. 113: 4476-4481. PubMed
  64. O'Donnell C, et al. 2015. Br J Cancer. 114: 37 - 43. PubMed
  65. Maltby S, et al. 2014. J Immunol. 193:4072. PubMed
  66. Jackson A, et al. 2014. J Leukoc Biol. 92:609. PubMed
  67. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  68. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  69. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  70. Fu R, et al. 2020. Sci Rep. 10:1455. PubMed
  71. Groza D, et al. 2018. Oncoimmunology. 7:e1424676. PubMed
  72. Kim SS, et al. 2022. Cancers (Basel). 14:. PubMed
  73. Yildirim Z, et al. 2022. EMBO Mol Med. 14:e15344. PubMed
  74. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  75. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  76. Gan C, et al. 2022. Respir Res. 23:32. PubMed
  77. El-Hindi K, et al. 2022. Int J Mol Sci. 23:. PubMed
  78. Meng W, et al. 2021. JCI Insight. 6:. PubMed
  79. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  80. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  81. Yu S, et al. 2016. J Immunol. 197: 256 - 265. PubMed
  82. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  83. Guo HX, et al. 2018. World J Gastroenterol. 24:1779. PubMed
  84. Karki R et al. 2018. Cell. 173(4):920-933 . PubMed
  85. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  86. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  87. Li Y, et al. 2021. Basic Res Cardiol. 116:30. PubMed
  88. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  89. Morgan PK, et al. 2021. J Biol Chem. 297:101341. PubMed
  90. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  91. Shen Y, et al. 2021. Comput Struct Biotechnol J. 19:5360. PubMed
  92. Zhang J, et al. 2021. Front Cardiovasc Med. 8:737652. PubMed
  93. Matsushita Y, et al. 2021. J Bone Miner Res. 36:1145. PubMed
  94. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  95. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  96. Palacios LM, et al. 2022. Biology (Basel). 11:. PubMed
  97. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  98. Jenull S, et al. 2021. Cell Reports. 36(3):109406. PubMed
  99. Yuan Q, et al. 2021. Cell Reports. 34(5):108724. PubMed
  100. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
  101. Barberio AE, et al. 2020. ACS Nano. 14:11238. PubMed
  102. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  103. Li T, et al. 2016. Cell Death Dis. 7:e2258. PubMed
  104. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  105. Tang E, et al. 2015. J Lipid Res. 56:358. PubMed
  106. Harel M, et al. 2020. Cell. 179(1):236-250.e18.. PubMed
  107. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  108. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  109. Agelidis A, et al. 2019. Front Immunol. 10:500. PubMed
  110. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  111. Truax AD et al. 2018. Cell host & microbe. 24(3):364-378 . PubMed
  112. Rashid K, et al. 2018. Sci Rep. 8:9023. PubMed
  113. Chen J, et al. 2022. Nat Commun. 13:6759. PubMed
  114. Wang S, et al. 2022. Front Immunol. 13:869061. PubMed
  115. Gopinathan G, et al. 2022. Mol Cancer Ther. 21:1030. PubMed
  116. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  117. Yu X, et al. 2021. Nature. 594:560. PubMed
  118. Wei Q, et al. 2021. Nat Commun. 12:2522. PubMed
  119. Liu Z, et al. 2015. Biol Reprod. 92:63. PubMed
  120. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  121. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  122. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  123. Tencati M, Tapping R 2016. Infect Immun . 84: 2904 - 2913. PubMed
  124. Liao Y, et al. 2017. Virol J. 10.1186/s12985-017-0801-x. PubMed
  125. Dong G, et al. 2017. Biochim Biophys Acta. 10.1016/j.bbadis.2017.08.005. PubMed
  126. Tamura R, et al. 2017. Inflamm Regen. 36:26:00. PubMed
  127. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  128. Demircioglu F, et al. 2020. Nat Commun. 11:1290. PubMed
  129. Kimura T, et al. 2020. Commun Biol. 0.527777778. PubMed
  130. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  131. Almutairi F, et al. 2021. Front Immunol. 12:772288. PubMed
  132. Dignum T, et al. 2021. Cell Rep. 36:109675. PubMed
  133. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  134. Sugimoto C, et al. 2022. Elife. 11:. PubMed
  135. Nabeta HW, et al. 2022. Front Cell Infect Microbiol. 12:976033. PubMed
  136. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  137. Kovacs L, et al. 2020. PLoS One. 15:e0240455. PubMed
  138. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  139. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  140. Hyatt L, et al. 2014. PLoS One. 9:109072. PubMed
  141. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  142. Sun P, et al. 2021. J Invest Dermatol. 141:1542. PubMed
  143. Li Y, et al. 2022. Clin Transl Immunology. 11:e1362. PubMed
  144. Sugita J, et al. 2021. Nat Commun. 12:1910. PubMed
  145. Glass A, et al. 2013. J Immunol. 190:4830. PubMed
  146. Izquierdo-Useros N, et al. 2014. J Immunol . 192:4852-4858. PubMed
  147. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  148. Liu Z, et al. 2016. J Biol Chem. 291: 1441 - 1447. PubMed
  149. Cheng XS, et al. 2020. J Cell Mol Med. 24:8391. PubMed
  150. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  151. Lumbroso D, et al. 2018. Front Immunol. 9:358. PubMed
  152. Simonneau M, et al. 2018. Oncotarget. 9:36457. PubMed
  153. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  154. Yuan B, et al. 2021. J Immunother Cancer. 9:. PubMed
  155. Wu X, et al. 2021. Elife. 10:. PubMed
  156. Wang B, et al. 2022. Nat Commun. 13:3821. PubMed
  157. Opzoomer JW, et al. 2021. Sci Adv. 7:eabg9518. PubMed
  158. Wang Q, et al. 2020. Res Sq. . PubMed
  159. Hofbauer D, et al. 2021. Immunity. 54(8):1772-1787.e9. PubMed
  160. Lin J, et al. 2017. Sci Rep. 7:41722. PubMed
  161. Yin T, et al. 2016. Sci Rep. 18:19534. PubMed
  162. Mitsuhashi A, et al. 2015. Nat Commun. 6: 8792. PubMed
  163. Eichin D, et al. 2015. PLoS One. 10: 0134721. PubMed
  164. Barman PK, et al. 2019. J Immunol. 202:2720. PubMed
  165. Das LM, et al. 2019. Autophagy. 15:813. PubMed
  166. Pelka K, et al. 2018. Immunity. 48:911. PubMed
  167. Lim D, et al. 2018. Front Physiol. 9:47. PubMed
  168. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  169. Lee J, et al. 2022. Nat Commun. 13:1516. PubMed
  170. Ma K, et al. 2021. J Leukoc Biol. 110:927. PubMed
  171. Kornstädt L, et al. 2021. Front Immunol. 11:607048. PubMed
  172. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  173. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  174. Wang H, et al. 2021. Malar J. 20:249. PubMed
  175. Chen W, et al. 2016. J Immunol. 197: 3554 - 3565. PubMed
  176. Enam SF, et al. 2020. J Neuroinflammation. 0.845138889. PubMed
  177. Li N, et al. 2021. eLife. 10:00. PubMed
  178. Penninger P, et al. 2021. STAR Protocols. 2(1):100352. PubMed
  179. Zhang F, et al. 2020. EMBO Mol Med. e12034:12. PubMed
  180. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  181. Kumaran Satyanarayanan S, et al. 2019. Nat Commun. 10:3471. PubMed
  182. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  183. Iizasa E, et al. 2021. Nat Commun. 12:2299. PubMed
  184. Hu M, et al. 2021. J Clin Invest. 131:. PubMed
  185. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  186. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  187. Zhu H, et al. 2021. Cell Metabolism. :. PubMed
  188. Kuai Y, et al. 2020. Theranostics. 5.099305556. PubMed
  189. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  190. Wang C, et al. 2017. J Ethnopharmacol. 10.1016/j.jep.2017.06.014. PubMed
  191. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  192. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  193. Xu M, et al. 2022. Genes Dis. 9:429. PubMed
  194. Myerson JW, et al. 2021. Nat Nanotechnol. Online ahead of print. PubMed
  195. McDonald B, et al. 2020. Cell Host Microbe. 28(5):660-668.e4. PubMed
  196. Devi S, et al. 2021. Immunity. 54(6):1219-1230.e7. PubMed
  197. Qin Q, et al. 2021. Cell Reports. 35(8):109161. PubMed
  198. Riedelberger M, et al. 2020. Bio Protoc. e3552:10. PubMed
  199. Michaud J, et al. 2017. BMC Microbiology . 10.1186/s12866-017-1036-0. PubMed
  200. Toomey CB, et al. 2018. Invest Ophthalmol Vis Sci. 59:662. PubMed
  201. Sun T, et al. 2017. Mucosal Immunol. 0.954861111. PubMed
  202. Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
  203. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  204. Bai B, et al. 2021. Theranostics. 11:6225. PubMed
  205. Huang Z, et al. 2021. Nat Commun. 12:145. PubMed
  206. Cho K, et al. 2021. iScience. 24:103117. PubMed
  207. Ma S, et al. 2022. Cell Rep. 38:110520. PubMed
  208. Sharma S, et al. 2021. Pathophysiology. 28:501. PubMed
  209. Nishida J, et al. 2022. STAR Protoc. 3:101306. PubMed
  210. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  211. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  212. Reimer E, et al. 2020. J Cell Sci. 134:00:00. PubMed
  213. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  214. Alonso-Herranz L, et al. 2020. Elife. 9:00. PubMed
  215. Pashover-Schallinger E, et al. 2012. FASEB J. 26:3891. PubMed
  216. Min C, et al. 2020. Cell Death Dis. 0.847916667. PubMed
  217. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  218. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  219. Sendler M, et al. 2020. Gastroenterology. 158:253. PubMed
  220. Pagan JD, et al. 2018. Cell. 172:564. PubMed
  221. Li H, et al. 2022. Gut Microbes. 14:2127456. PubMed
  222. Li Y, et al. 2022. Front Cardiovasc Med. 9:830781. PubMed
  223. Sun S, et al. 2021. Front Immunol. 12:777665. PubMed
  224. Fields L, et al. 2021. Mol Ther. 29:2554. PubMed
  225. Jiang Y, et al. 2021. Cell Death Differ. 28:3009. PubMed
  226. Murr NJ, et al. 2021. Nutrients. 13:. PubMed
  227. Zhang S, et al. 2014. Eur J Pharmacol. 733:45. PubMed
  228. Kumagai S, et al. 2016. Cardiovasc Res. 109: 272 - 282. PubMed
  229. Ikezoe K, et al. 2016. Sci Rep. 6: 25781. PubMed
  230. Hasegawa T, et al. 2020. Sci Rep. 10:13480. PubMed
  231. Wang H, et al. 2020. Nat Mater. 1.655555556. PubMed
  232. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  233. Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
  234. Li B, et al. 2019. Oncol Rep. 41:608. PubMed
  235. Hu Y, et al. 2021. Cell Death Dis. 12:743. PubMed
  236. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  237. Kolodkin-Gal D, et al. 2021. Gut. Online ahead of print. PubMed
  238. Fu Y, et al. 2021. Front Cell Dev Biol. 9:689727. PubMed
  239. Andriessen EMMA, et al. 2021. EMBO Mol Med. 13:e11754. PubMed
  240. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  241. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  242. Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed
  243. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  244. Morikawa M, et al. 2016. PLoS One. 11:e0163607. PubMed
  245. Yahuafai J, et al. 2014. J Control Release. 28:192. PubMed
  246. Sun X, et al. 2020. Cell Metabolism. 31(1):189-206.e8.. PubMed
  247. Yu JM, et al. 2019. Nat Commun. 4.388888889. PubMed
  248. Nowak W, et al. 2020. EBioMedicine. 50:290-305.. PubMed
  249. Hightower RM, et al. 2019. Mol Ther. 28:189. PubMed
  250. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  251. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  252. Bitschar K, et al. 2019. Nat Commun. 10:2730. PubMed
  253. Lamb T, et al. 2022. Toxics. 10:. PubMed
  254. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  255. Song J, et al. 2021. Am J Physiol Heart Circ Physiol. 320:H323. PubMed
  256. Li ZL, et al. 2021. Mol Ther Nucleic Acids. 25:502. PubMed
  257. Tang Z, et al. 2021. Stem Cell Res Ther. 12:397. PubMed
  258. Al-Barwani F, et al. 2014. PLoS One. 9:104523. PubMed
  259. Lieber S, et al. 2014. Mol Pharmacol. 87:162. PubMed
  260. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  261. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  262. Yang H, et al. 2020. Arterioscler Thromb Vasc Biol. 40:e350. PubMed
  263. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  264. Sundar I, et al. 2017. Biochem Biophys Res Commun. 10.1016/j.bbrc.2017.09.157. PubMed
  265. Maniati E, et al. 2020. Cell Rep. 30:525. PubMed
  266. Han MS, et al. 2020. Proc Natl Acad Sci U S A. 117:2751. PubMed
  267. Doni A, et al. 2021. Nat Commun. 12:3739. PubMed
  268. Kang M, et al. 2021. Front Cell Dev Biol. 8:596622. PubMed
  269. He S, et al. 2021. Front Pharmacol. 12:743837. PubMed
  270. Wang S, et al. 2022. J Inflamm Res. 14:7107. PubMed
  271. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  272. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  273. Valkenburg S, et al. 2016. Sci Rep. 6:22666. PubMed
  274. Wang Y, et al. 2020. eLife. 9:e57438.. PubMed
  275. Chen M, et al. 2019. Cell Stem Cell. 25:501. PubMed
  276. Moufarrij S, et al. 2020. Sci Rep. 10:3470. PubMed
  277. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  278. William M, et al. 2018. J Immunol. 200:4102. PubMed
  279. Ayturk UM, et al. 2020. J Bone Miner Res. 35:1981. PubMed
  280. Huang T, et al. 2022. Nat Commun. 13:3489. PubMed
  281. Sun L, et al. 2022. Adv Sci (Weinh). 9:e2104051. PubMed
  282. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  283. Gao X, et al. 2021. Nature. 589:591. PubMed
  284. Lee SA, et al. 2021. Cells. 10:. PubMed
  285. Fan ZP, et al. 2021. Front Immunol. 12:743354. PubMed
  286. Xiang Y, et al. 2014. Proc Natl Acad Sci U S A. . PubMed
  287. Erin N, et al. 2015. Brain Behav Immun. 48: 174-185. PubMed
  288. Peng X, et al. 2015. J Immunol. 195: 2797-2805. PubMed
  289. Tsunekuni K, et al. 2020. J Clin Med. 9:00. PubMed
  290. Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed
  291. Hering L, et al. 2020. Front Immunol. 1.747222222. PubMed
  292. Silva-Cayetano A, et al. 2020. Med. 2(3):243-262.e8. PubMed
  293. Asada S, et al. 2018. Nat Commun. 9:2733. PubMed
  294. Zhang J, et al. 2018. Oncoimmunology. 7:e1461301. PubMed
  295. Hayashida E, et al. 2019. J Neuroinflammation. 0.789583333. PubMed
  296. Wang S, et al. 2020. J Cell Mol Med. 24:722. PubMed
  297. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  298. Xu M, et al. 2020. Cell. 178(6):1478-1492.e20.. PubMed
  299. Wang Q, et al. 2020. Respir Res. 0.981944444. PubMed
  300. Sugita Y, et al. 2021. Oncol Rep. 45:. PubMed
  301. Zhang F, et al. 2021. J Immunol Res. 2021:5521051. PubMed
  302. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  303. Liu Q, et al. 2021. Adv Mater. 33:e2102852. PubMed
  304. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  305. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  306. Nakayama Y, et al. 2020. Proc Natl Acad Sci U S A. 117:14365. PubMed
  307. Smith R, et al. 2016. J Leukoc Biol. 100:371-80. PubMed
  308. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  309. Zhang J, et al. 2014. J Immunol. 193:5149. PubMed
  310. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  311. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  312. Lee MC, et al. 2017. J Immunol. 198:3565. PubMed
  313. Perrotta C, et al. 2018. Front Immunol. 9:1186. PubMed
  314. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  315. Zhu Y, et al. 2021. Int J Oral Sci. 13:25. PubMed
  316. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  317. Horwitz E, et al. 2014. Cancer Discovery. 4:730. PubMed
  318. Wang Y, et al. 2015. Sci Rep. 5:16973. PubMed
  319. Ang QY, et al. 2020. Cell. 181(6):1263-1275.e16. PubMed
  320. Wang X, et al. 2020. Immunity. 328:52. PubMed
  321. Li Z et al. 2018. Immunity. 49(4):640-653 . PubMed
  322. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  323. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  324. Wang L, et al. 2020. J Nanobiotechnology. 18:38. PubMed
  325. Jiang M, et al. 2021. Front Pharmacol. 12:657486. PubMed
  326. Song HY, et al. 2021. Mol Ther. S1525-0016:00472-X. PubMed
  327. Luo ZW, et al. 2021. Int J Nanomedicine. 16:2949. PubMed
  328. Wang X, et al. 2021. Sci Transl Med. 13:. PubMed
  329. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  330. Lau A, et al. 2022. Sci Adv. 8:eabm0142. PubMed
  331. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  332. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  333. Petty AJ, et al. 2021. JCI Insight. 6:. PubMed
  334. Gawish R, et al. 2022. Elife. 11:. PubMed
  335. Jia J, et al. 2022. Nat Commun. 13:6804. PubMed
  336. Feng L, et al. 2014. Biochem Pharmacol. 89:109. PubMed
  337. Liu Y, et al. 2019. Am J Physiol Cell Physiol. 317:C762. PubMed
  338. Samir P, et al. 2019. Nature. 573:590. PubMed
  339. Abe H, et al. 2019. Nat Commun. 10:2824. PubMed
  340. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  341. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  342. Xu Z, et al. 2022. Cell Death Dis. 13:502. PubMed
  343. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  344. Wu KKL, et al. 2021. Nat Commun. 12:6637. PubMed
  345. Witas R, et al. 2021. Int J Mol Sci. 22:. PubMed
RRID
AB_893486 (BioLegend Cat. No. 123109)
AB_893486 (BioLegend Cat. No. 123110)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account