- Clone
- 4A6 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Plasmacytoid dendritic cell-specific receptor
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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139203 | 25 µg | £89 | ||||
139204 | 100 µg | £204 |
PDC-TREM, also known as plasmacytoid dendritic cell (PDC) -specific receptor, is a member of the TREM receptor family. It is a transmembrane protein composed of an extracellular region with one V-type Ig domain, a transmembrane region with a lysine residue, and a cytoplasmic domain with no recognized signaling motifs. The lysine present in the transmembrane region allows PDC-TREM to form a complex with DAP12 and Plexin-A1. PI3K and Erk 1/2 are involved in the signal transduction of this complex. PDC-TREM is expressed in TLR-activated PDCs and is involved in the production of IFN-α.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant soluble PDC-TREM
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: Western blot1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Watarai H, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2993. (WB)
- Rahim MM, et al. 2013. J. Immunol. 190:3994. PubMed.
- Product Citations
-
- RRID
-
AB_10613471 (BioLegend Cat. No. 139203)
AB_10613471 (BioLegend Cat. No. 139204)
Antigen Details
- Structure
- Member of the TREM receptor family. Type I protein composed of an extracellular region with a single V-type Ig domain, a transmembrane domain with a lysine residue and a cytoplasmic domain with no recognized signaling motifs.
- Distribution
- Expressed on TLR activated plasmacytoid dendritic cells (PDC)
- Function
- Signal transduction, induces the production of IFN-α
- Interaction
- DAP12, Plexin-A1, PI3K, Erk 1/2
- Cell Type
- Dendritic cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
-
1. Jill W, et al. 2009. Curr. Opin. Immunol. 21:38.
2. Lanier LL. 2009. Immunol. Rev. 227:150. - Gene ID
- 328830 View all products for this Gene ID
- UniProt
- View information about PDC-TREM on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All PDC-TREM Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-mouse PDC-TREM | 4A6 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-mouse PDC-TREM
C57BL/6 mouse splenocytes activated overnight with CpG-A and...
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