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PE/Cyanine7 anti-human CD24 Antibody

Pricing & Availability
Clone
ML5 (See other available formats)
Regulatory Status
RUO
Workshop
V CD24.5
Other Names
Ly-52, Heat Stable Antigen (HSA), Nectadrin, BA-1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
ML-5_PECy7_092109
Human peripheral blood lymphocytes stained with ML-5 PE/Cyanine7
  • ML-5_PECy7_092109
    Human peripheral blood lymphocytes stained with ML-5 PE/Cyanine7
Compare all formats See PE/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
311119 25 tests £109
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311120 100 tests £249
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Description

CD24 is a 35-45 kD glycosylphosphatidylinositol (GPI)-linked protein also known as heat stable antigen (HSA), BA-1, Ly-52, and nectadrin. It is expressed on the surface of B cells (but not plasma cells), granulocytes, follicular dendritic cells, and epithelial cells. CD24 may play a role in the regulation of B-cell proliferation and maturation. CD24 crosslinking induces a Ca2+ flux in mature B cells. CD24 has been shown to interact with CD62P (P-selectin).

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescence microscopy3.

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. Eds. 1995. Leukocyte Typing V:White Cell Differentiation Antigens. Oxford University Press. New York.
  2. McMichael A, et al. 1987. Leucocyte Typing III. Oxford University Press. New York.
  3. Yang GP, et al. 1999. Nucleic Acids Research 27:1517. (IF)
  4. Kristiansen G, et al. 2003. Clin. Cancer Res. 9:4906. (FC)
Product Citations
  1. Xu Y, et al. 2022. Nat Genet. 54:1690. PubMed
  2. Bagnara D, et al. 2015. J Immunol. 195: 3716 - 3724. PubMed
  3. Hamilton K, et al. 2013. Carcinogenesis. 34:2647. PubMed
  4. Earley AM, et al. 2021. Sci Rep. 11:22257. PubMed
  5. Girard MC, et al. 2021. Sci Rep. 11:5511. PubMed
  6. Deshmukh A, et al. 2018. Cancers (Basel). 10. PubMed
  7. Joosten S, et al. 2016. PLoS Pathog. 12: 1005687. PubMed
  8. Hong D, et al. 2018. Mol Cancer Res. 2.022222222. PubMed
  9. Aravena O, et al. 2017. Arthritis Res Ther. 19:8. PubMed
  10. Ames E, et al. 2015. J Immunol. 195: 4010 - 4019. PubMed
  11. Mohiuddin M, et al. 2016. Nat Commun. 7: 11138. PubMed
  12. Luo M et al. 2018. Cell metabolism. 28(1):69-86 . PubMed
  13. Fritz AJ, et al. 2020. J Cell Physiol. 235:7261. PubMed
  14. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  15. Ordonez M, et al. 2012. Hum Mol Genet. 2.715972222. PubMed
  16. Izar B, et al. 2020. Nat Med. 26:1271. PubMed
  17. Slyper M, et al. 2020. Nat Med. 26:792. PubMed
  18. Upasani V, et al. 2019. Front Immunol. 2.152777778. PubMed
RRID
AB_2259843 (BioLegend Cat. No. 311119)
AB_2259843 (BioLegend Cat. No. 311120)

Antigen Details

Structure
GPI-linked glycoprotein, 35-45 kD
Distribution

B cells, granulocytes, epithelial cells

Function
B cell proliferation and differentiation
Ligand/Receptor
CD62P (P-Selectin)
Cell Type
B cells, Epithelial cells, Granulocytes
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Schlossman S, et al. Eds. 1995. Leukocyte Typing V. Oxford University Press. New York.

Gene ID
100133941 View all products for this Gene ID
UniProt
View information about CD24 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 08/09/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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