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PE/Cyanine7 anti-human CD56 (NCAM) Antibody

Pricing & Availability
Clone
HCD56 (See other available formats)
Regulatory Status
RUO
Other Names
Leu-19, NKH1
Isotype
Mouse IgG1, κ
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Product Citations
publications
HCD56_PECy7_070207
Human peripheral blood lymphocytes stained with HCD56 PE/Cyanine7
  • HCD56_PECy7_070207
    Human peripheral blood lymphocytes stained with HCD56 PE/Cyanine7
Compare all formats See PE/Cyanine7 spectral data
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318317 25 tests £105
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318318 100 tests £213
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Description

CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
Product Citations
  1. Hagel J, et al. 2021. J Immunol. 206:3073. PubMed
  2. Andreano E, et al. 2023. Nat Commun. 14:53. PubMed
  3. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  4. Calabrese DR, et al. 2020. J Clin Invest. . PubMed
  5. Wang H, et al. 2022. Front Immunol. 13:852436. PubMed
  6. Park SY, et al. 2022. NPJ Vaccines. 7:123. PubMed
  7. Kim JT, et al. 2022. Nat Commun. 13:121. PubMed
  8. Figueroa-Romero C, et al. 2022. Front Immunol. 13:773288. PubMed
  9. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  10. Wiernik A, et al. 2013. Clin Cancer Res. 19:3844. PubMed
  11. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  12. Wurzer H, et al. 2021. Front Immunol. 12:619069. PubMed
  13. Bernareggi D, et al. 2022. Nat Commun. 13:1899. PubMed
  14. Arvindam US, et al. 2021. Leukemia. 35:1586. PubMed
  15. Izmirly AM, et al. 2022. PLoS Pathog. 18:e1009903. PubMed
  16. Romee R, et al. 2013. Blood. 121:3599. PubMed
  17. Cheent K, et al. 2013. Proc Natl Acad Sci U S A. 110:16981. PubMed
  18. Gleason M, et al. 2014. Blood. 123:3016. PubMed
  19. Mao Y, et al. 2016. Blood. 128: 1475 - 1489. PubMed
  20. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  21. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  22. Nabet BY, et al. 2020. Cell. 183(2):363-376.e13. PubMed
  23. Laroni A, et al. 2016. J Autoimmun. 72:8-18. PubMed
  24. Cooper GE, et al. 2018. Front Immunol. 9:1671. PubMed
  25. Singh N, et al. 2017. J Endocrinol. 235:69. PubMed
  26. Mishra HK, et al. 2021. Front Immunol. 12:711621. PubMed
  27. Zhu S, et al. 2022. J Oncol. 2022:8724933. PubMed
  28. Liu Y, et al. 2017. Oncogene. 10.1038/onc.2017.209. PubMed
  29. Hakimi AA, et al. 2019. Cancer Discov. 9:510. PubMed
  30. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  31. Madhavi V, et al. 2015. J Infect Dis. 211:529. PubMed
  32. Murdock BJ, et al. 2021. JCI Insight. 6:. PubMed
  33. Gleason M, et al. 2012. Mol Cancer Ther. 11:2674. PubMed
  34. Fisher JG, et al. 2021. Front Oncol. 11:785635. PubMed
  35. Zhao NQ, et al. 2020. PLoS One. 15:e0238347. PubMed
  36. Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed
  37. Andreano E, et al. 2021. Nature. Online ahead of print. PubMed
  38. Hansen A, et al. 2016. Sci Rep. 6:35406. PubMed
  39. Terszowski G, et al. 2014. J Immunol. 192:5618. PubMed
  40. Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed
  41. Felices M, et al. 2018. JCI Insight. 3. PubMed
  42. Van der Meer JM, et al. 2020. Cancer Immunol Immunother. . PubMed
  43. Woods E, et al. 2021. NPJ Vaccines. 6:117. PubMed
  44. Chen YP, et al. 2020. Cell Res. 30:1024. PubMed
  45. Zhang C, et al. 2021. Cancer Biol Med. :. PubMed
  46. Kucykowicz S, et al. 2022. STAR Protoc. 3:101356. PubMed
  47. Agelidis A, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.06.041. PubMed
  48. Kwant-Mitchell A, et al. 2009. PLoS One. 4:e8379. PubMed
  49. Wang S, et al. 2022. Cancer Immunol Immunother. Online ahead of print. PubMed
  50. Parent AV, et al. 2021. Cell Reports. 36(7):109538. PubMed
  51. Sadallah S, et al. 2016. J Immunol. 197: 1663 - 1671. PubMed
  52. Vallera D, et al. 2016. Clin Cancer Res. 22: 3440 - 3450. PubMed
RRID
AB_604099 (BioLegend Cat. No. 318317)
AB_604099 (BioLegend Cat. No. 318318)

Antigen Details

Structure
Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution

NK cells, T subset, neural tissue, some LGL and myeloid leukemias

Function
Adhesion
Ligand/Receptor
Heparin sulfate
Cell Type
B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Lanier L, et al. 1991. J. Immunol. 146:4421.
2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71.
3. Cremer H, et al. 1994. Nature 367:455.

Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD56 on UniProt.org

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Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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