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PE/Cyanine7 anti-human/mouse CXCR7 Antibody

Pricing & Availability
Clone
8F11-M16 (See other available formats)
Regulatory Status
RUO
Other Names
Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159
Isotype
Mouse IgG2b, κ
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Product Citations
publications
8F11-M16_PECy7_CXCR7_Antibody_FC_050515
CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 8F11-M16) PE/Cyanine7 (filled histogram) or mouse IgG2b, κ PE/Cyanine7 isotype control (open histogram).
  • 8F11-M16_PECy7_CXCR7_Antibody_FC_050515
    CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 8F11-M16) PE/Cyanine7 (filled histogram) or mouse IgG2b, κ PE/Cyanine7 isotype control (open histogram).
Compare all formats See PE/Cyanine7 spectral data
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331115 25 tests £133
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331116 100 tests £269
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Description

CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. Binding of ligand to CXCR7 induces proliferation and migration of immature neurons, glia and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. Surface expression of CXCR7 was also reported to be on tumor cells, activated endothelial cells, fetal liver cells, and other cell types.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CXCR7 transfectant
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Soehnlein O, et al. 2013. EMBO Mol. Med. 5:471. (FC) PubMed
  2. Balabanian K, et al. 2012. J. Transl. Med. 10:251. (FC) PubMed
Product Citations
  1. Ceholski D, et al. 2017. Stem Cell Res. 10.1016/j.scr.2017.06.015. PubMed
RRID
AB_2565678 (BioLegend Cat. No. 331115)
AB_2565678 (BioLegend Cat. No. 331116)

Antigen Details

Structure
G protein-coupled receptor super family
Distribution

Monocytes, B cells, T cells and mature dendritic cells

Ligand/Receptor
CXCL12/SDF-1 and CXCL11/I-TAC
Cell Sources
On a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells
Cell Type
B cells, Dendritic cells, Monocytes, T cells
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
2. Infantino S, et al. 2006. J. Immunol. 176:2197.

Regulation
Regulates the trafficking and activation of leukocytes
Gene ID
12778 View all products for this Gene ID 57007 View all products for this Gene ID
UniProt
View information about CXCR7 on UniProt.org

Related FAQs

Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?

Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.

Go To Top Version: 1    Revision Date: 05/06/2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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