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PE/Dazzle™ 594 anti-mouse CD186 (CXCR6) Antibody

Pricing & Availability
Clone
SA051D1 (See other available formats)
Regulatory Status
RUO
Other Names
CXCR6, Chemokine (C-X-C motif) receptor 6, BONZO, STRL33, chemokine receptor 6, CD 186, CXC-R6, CXCR-6, C-X-C chemokine receptor type 6
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
SA051D1_PEDazzle594_CD186_Antibody_012618
C57BL/6 mouse splenocytes were stained with CD3e APC and CD186 (clone SA051D1) PE/Dazzle™ 594 (top) or rat IgG2b, κ PE/Dazzle™ 594 isotype control (bottom).
  • SA051D1_PEDazzle594_CD186_Antibody_012618
    C57BL/6 mouse splenocytes were stained with CD3e APC and CD186 (clone SA051D1) PE/Dazzle™ 594 (top) or rat IgG2b, κ PE/Dazzle™ 594 isotype control (bottom).
Compare all formats See PE/Dazzle™ 594 spectral data
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151116 25 µg £113
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151117 100 µg £262
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Description

CD186, or CXCR6, is a 39 kD G-protein coupled chemokine receptor with seven transmembrane-spanning regions. Its ligand is CXCL16. It is expressed on different T cell subsets and is upregulated in activated T cells. Expression of CXCR6 is correlated with increased inflammatory responses and seems to contribute to liver fibrosis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
mCXCR6-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

 

* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Anadon CM, et al. 2022. Cancer Cell. 40:545. PubMed
  2. du Halgouet A, et al. 2023. Immunity. 56:78. PubMed
  3. Zander R, et al. 2022. Immunity. 55:475. PubMed
  4. Kedmi R, et al. 2022. Nature. 610:737. PubMed
  5. Zander R, et al. 2022. Elife. 11:. PubMed
  6. Lopes N, et al. 2022. Cell Rep Med. 3:100812. PubMed
  7. Zander R, et al. 2020. Immunity. 51(6):1028-1042.e4.. PubMed
RRID
AB_2721699 (BioLegend Cat. No. 151116)
AB_2721699 (BioLegend Cat. No. 151117)

Antigen Details

Structure
G-protein coupled receptor 1 family.
Distribution

T cells and natural killer T (NKT) cells.

Function
Chemotaxis and the development of T cells.
Ligand/Receptor
CXCL16.
Cell Type
NKT cells, T cells
Biology Area
Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Kim CH, et al. 2001. J. Clin. Invest. 107:595.
2. Heesch K, et al. 2014. PLoS One. 9:5.
3. Wehr A, et al. 2013. J. Immunol. 190:5226.

Gene ID
80901 View all products for this Gene ID
UniProt
View information about CD186 on UniProt.org
Go To Top Version: 0    Revision Date: 11/16/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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