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- Clone
- A18241B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CR, 29 KDa calbindin, CAB29, CALB2, Calbindin 2, Calbindin D29K, CAL2
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot of purified anti-Calretinin antibody (clone A18241B). Lane 1: Molecular weight marker; Lane 2: 20 µg of human cerebellum lysate; Lane 3: 20 µg of mouse cerebellum lysate; Lane 4: 20 µg of rat cerebellum lysate. The blot was incubated with 0.1 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 871401 | 25 µg | £73 | ||||
| 871402 | 100 µg | £189 | ||||
Calretinin is a calcium-binding protein that is abundantly expressed in interneurons and multiple regions of the brain, including the brainstem, hypothalamus, hippocampus, and cerebellum. Calretinin is involved in regulating intracellular calcium signaling and modulating neuronal excitability. Loss and reorganization of calretinin-positive interneurons have been indicated as possible cause in human epilepsy. In addition, calretinin is considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CALB2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 2.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2861109 (BioLegend Cat. No. 871401)
AB_2861109 (BioLegend Cat. No. 871402)
Antigen Details
- Structure
- Human calretinin is a 271 amino acid protein with a predicted molecular mass of 31 kD.
- Distribution
-
Tissue distribution: Brain
Cellular distribution: Cytosol, cytoskeleton, nucleus, plasma membrane - Function
- Calretinin regulates intracellular calcium signaling and modulates neuronal excitability.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Synaptic Biology
- Antigen References
-
- Wörthmüller J, et al. 2018. Oncotarget. 9(91):36256-36272.
- Christel CJ, et al. 2012. J Biol Chem. 287(47):39766-75.
- Tóth K, et al. 2010. Brain. 133(9):2763-77.
- Gene ID
- 794 View all products for this Gene ID
- UniProt
- View information about Calretinin on UniProt.org
Other Formats
View All Calretinin Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-Calretinin | A18241B | WB |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-Calretinin
Western blot of purified anti-Calretinin antibody (clone A18...
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