- Clone
- A22071J (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Coagulation Factor III, Tissue Factor, TF, Thromboplastin, platelet tissue factor, factor III, factor 3, F3, F-3, TFA, P13726
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
681451 | 25 µg | £117 | ||||
681452 | 100 µg | £281 |
CD142, also known as Tissue Factor (TF), Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells. CD142 is a high-affinity receptor for coagulation factor VII/VIIa and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant fragment of human CD142
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody (clone A22071J) is not recommended for immunocytochemistry (ICC) or Immunohistochemistry in formalin-fixed paraffin-embedded tissue (IHC-P).
- RRID
-
AB_3662336 (BioLegend Cat. No. 681451)
AB_3662336 (BioLegend Cat. No. 681452)
Antigen Details
- Structure
- 45 kD Type I transmembrane glycoprotein
- Distribution
-
Smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells, astrocytes, myocardium, liver stromal cells, pancreas cell, stimulated endothelial cells, stimulated monocytes
- Function
- Blood coagulation
- Ligand/Receptor
- Coagulation Factor VIIa
- Cell Type
- Astrocytes, Endothelial cells, Epithelial cells, Fibroblasts
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Carson SD, et al. 1994. Blood. 84:526-34.
- McComb RD, et al. 1991. Am J Pathol. 139:491-4.
- Whittle SM, et al. 1995. Thromb Res. 79:451-9.
- Gene ID
- 2152 View all products for this Gene ID
- UniProt
- View information about CD142 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All CD142 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-CD142 | A22071J | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-CD142
Whole cell extracts (15 µg total protein per lane) from indi...
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