- Clone
- 1D8D9 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- cAMP receptor protein, cAMP regulatory protein, Catabolite gene activator, cap, csm
- Isotype
- Mouse IgG1
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
664304 | 100 µg | £221 |
CRP (also known as cAMP receptor protein) is a regulatory protein in bacteria. CRP binding to cAMP leads to conformational changes in CRP resulting in a dramatic increase in its binding to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA and acts as a negative regulator of its own synthesis.
Product DetailsProduct Details
- Verified Reactivity
- E. coli
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified protein
- Formulation
- Phosphate-buffered solution, pH 7.2.
- Preparation
- The antibody was purified by affinity chromatography.
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2565553 (BioLegend Cat. No. 664304)
Antigen Details
- Structure
- 210 amino acids with a predicted molecular weight of approximately 23.5 kD.
- Distribution
-
Bacteria.
- Function
- Transcriptional regulator in bacteria.
- Ligand/Receptor
- cAMP
- Biology Area
- Cell Biology, Transcription Factors
- Antigen References
-
1. Busby S, et al. 1999. J. Mol. Biol. 293:199.
2. Lawson CL, et al. 2004. Curr. Opin. Struct. Biol. 14:10.
3. Hudson BP, et al. 2009. Proc. Natl. Acad. Sci. USA 106:19830. - Gene ID
- 1036667 View all products for this Gene ID
- UniProt
- View information about CRP on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CRP Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-E. coli CRP | 1D8D9 | WB |
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Purified anti-E. coli CRP
Western blot analysis of 50 ng recombinant CRP protein (lane...
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