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Purified anti-FOLR1 (Folate Binding Protein) Antibody (Previously Covance catalog# SIG-3619)

Pricing & Availability
Clone
LK26 (See other available formats)
Regulatory Status
RUO
Other Names
Folate receptor alpha, FR-alpha, KB cells FBP, folate binding protein, folate receptor, adult, adult folate-binding protein, ovarian tumor-associated antigen MOv18
Previously
Signet Catalog# 619-01
Covance Catalog# SIG-3619
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
LK26_Purified_FORL1_Antibody_123118.png
IHC staining of purified anti-FOLR1 (Folate Binding Protein) antibody (clone LK26) on frozen human placenta tissue. The tissue was incubated with a 1:40 dilution of the primary antibody overnight at 4°C. BioLegend's Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
  • LK26_Purified_FORL1_Antibody_123118.png
    IHC staining of purified anti-FOLR1 (Folate Binding Protein) antibody (clone LK26) on frozen human placenta tissue. The tissue was incubated with a 1:40 dilution of the primary antibody overnight at 4°C. BioLegend's Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
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908301 1 mL £413
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Description

Folate receptor (FOLR1), also known as folate receptor alpha, is a folate-binding protein (FBP) expressed in adults. It has high affinity for folic acid and its metabolites, including 5-methyltetrahydrofolate (5-MTF), the biologically active form of folic acid used for DNA synthesis and the cysteine cycle. FOLR1 mediates intracellular delivery of 5-MTF. FOLR1 is overexpressed in a variety of tumors, including breast, colorectal, and brain.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was generated against gestational choriocarcinoma cell line, Lu-75 and detects folate-binding protein (FBP).
Formulation
Phosphate-buffered solution with BSA + 0.09% NaN3.

Previous lots of this product may have been formulated with 0.1% or 0.05% NaN3 instead of 0.09% NaN3. For further information please contact BioLegend Technical Support or Customer Service.
Preparation
The antibody was purified by affinity chromatography.
Storage & Handling
Store between 2°C and 8°C.
Application

IHC-F - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a dilution of 1:40 is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Hviid TV, et al. 1999. Prenat Diagn. 19: 271.
  2. Chesa-Garin P, et al. 1993. Am J Pathol. 142: 557.
  3. Rettig WJ, et al. 1985. Int J Cancer. 35:469.
RRID
AB_2565084 (BioLegend Cat. No. 908301)

Antigen Details

Structure
The LK26 antigen is a 35-40 kD cell surface glycoprotein
Gene ID
2348 View all products for this Gene ID
UniProt
View information about FOLR1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 6    Revision Date: 02/08/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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