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- Clone
- QA18A49 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- 4-1BB, ILA, CD137, TNFRSF9
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
PHA-stimulated (3days) human peripheral blood mononuclear cells were stained with anti-human CD137 (4-1BB) recombinant (clone QA18A49) purified (left) or purified mouse IgG1, κ isotype control (right), followed by goat anti-mouse IgG APC. Cells were co-stained with CD3 PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 370902 | 100 µg | £89 | ||||
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Recombinant human CD137 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
QA18A49 clone of antibody is able to completely block the binding of clone 4B4-1 to CD137 on cell surface.
- RRID
-
AB_2890804 (BioLegend Cat. No. 370902)
Antigen Details
- Structure
- TNFR superfamily, type I transmembrane protein, 30 kD
- Distribution
-
Activated T cells
- Function
- T cell costimulation
- Ligand/Receptor
- 4-1BB ligand
- Cell Type
- Lymphocytes, NK cells, NKT cells, T cells
- Biology Area
- Adaptive Immunity, Costimulatory Molecules, Immuno-Oncology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Gruss HJ & Dower SK. 1995. Blood. 85:3378-404.
- Sica G & Chen L. 2000. Adv Exp Med Biol. 465:355-62.
- Alderson MR, et al. 1994. Eur J Immunol. 24:2219-27.
- Schwarz H, et al. 1996. Blood. 87:2839-45.
- Gene ID
- 3604 View all products for this Gene ID
- UniProt
- View information about CD137 on UniProt.org
Related FAQs
Other Formats
View All CD137 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD137 (4-1BB) Recombinant Antibody | QA18A49 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD137 (4-1BB) Recombinant Antibody
PHA-stimulated (3days) human peripheral blood mononuclear ce...
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