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- Clone
- S22025B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- NKAT4, Killer Cell Immunoglobulin-Like Receptor 3DL2
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human peripheral blood lymphocytes were stained with anti-human CD56 APC and purified anti-human CD158k (KIR3DL2) (clone S22025B) (left) or purified mouse IgG1, к isotype control (right), followed by goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 389602 | 100 µg | £197 | ||||
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 15 polymorphic KIR genes have been reported in humans. CD158k is a 70 kD three extracellular Ig domain glycoprotein that presents as a disulphide-bonded homodimer extracellularly. The intracellular long cytoplasmic tail of CD158k contains two ITIM domains. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR3DL2 binds to a number of different MHC class 1 molecules depending on the viral peptide sequence presented.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KIR3DL2-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Based on in-house testing on different KIR-expressing transfectants, clone S22025B does not interact with other KIR protein family members.
- RRID
-
AB_3662347 (BioLegend Cat. No. 389602)
Antigen Details
- Structure
- 70 kD three Ig-like extracellular domain glycoprotein
- Distribution
-
Subset of NK cells, subset of T cells
- Function
- NK Cell regulation
- Ligand/Receptor
- MHC Class 1 molecules
- Cell Type
- Lymphocytes, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
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- Colonna M. et al. 1995. Science. 268:405-8.
- Lanier LL. 2005. Annu Rev Immunol. 23:225-74.
- Hansasuta P, et al. 2004. Eur J immunol. 34:1673-9.
- Gene ID
- 3812 View all products for this Gene ID
- UniProt
- View information about CD158k on UniProt.org
Related FAQs
Other Formats
View All CD158k Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD158k (KIR3DL2) | S22025B | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD158k (KIR3DL2)
Human peripheral blood lymphocytes were stained with anti-hu...
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