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Purified anti-human CD161 Antibody

Pricing & Availability
Clone
W18070C (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1A
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W18070C_PURE_CD161_Antibody_1_061120
Human peripheral blood lymphocytes were stained with purified CD161 (clone W18070C) (left) or purified rat IgG2a, κ isotype control (right) followed by goat anti-rat IgG PE and CD4 APC.
  • W18070C_PURE_CD161_Antibody_1_061120
    Human peripheral blood lymphocytes were stained with purified CD161 (clone W18070C) (left) or purified rat IgG2a, κ isotype control (right) followed by goat anti-rat IgG PE and CD4 APC.
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307502 100 µg £94
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Description

CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human CD161 transfected cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2860820 (BioLegend Cat. No. 307502)

Antigen Details

Structure
Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily
Distribution

NK cells, T subset, subset of CD3+ thymocytes

Ligand/Receptor
LLT-1 (Lectin-like transcript-1)
Cell Type
NK cells, T cells, Thymocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References
  1. Takahashi T, et al. 2006. J Immunol. 176:211-6.
  2. Cosmi L, et al. 2008. J Exp Med. 205:1903-16.
  3. Aldemir H, et al. 2005. J Immunol. 175:7791-5.
  4. Rosen DB, et al. 2008. J Immunol. 180:6508-17.
Gene ID
3820 View all products for this Gene ID
UniProt
View information about CD161 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 06/11/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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