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- Clone
- QA21A13 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- BLR1, MDR15
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with purified anti-human CXCR5 recombinant (clone QA21A13) (left) or purified mouse IgG1, κ isotype control (right) followed by goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 382402 | 100 µg | £182 | ||||
CD185, also known as CXCR5, is a 42 kD G-protein coupled receptor with seven transmembrane regions. CXCR5 is expressed by mature B cells, follicular helper T cells, Burkitt’s lymphoma cells and a subset of neurons, and mediates cell migration to the B cell follicles in the secondary lymphoid organs. The ligand of CXCR5 is CXCL13 (BLC).
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA21A13 can completely block the binding of clone J252D4 on target cells.
- RRID
-
AB_2927811 (BioLegend Cat. No. 382402)
Antigen Details
- Structure
- G-protein coupled receptor, 7 transmembrane regions, 42 kD
- Distribution
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Mature B cells, Follicular helper T cells, and Burkitt's lymphoma cells.
- Function
- Mediates cell migration to the B cell follicles in the secondary lymphoid organs
- Ligand/Receptor
- CXCL13
- Cell Type
- B cells, Tfh
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
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- Ma CS, et al. 2012. J Exp Med. 209:1241-53.
- León B, et al. 2012. Nat. Immunol. 13:681-90.
- Crotty S. 2011. Annu Rev Immunol. 29:621-63.
- Kerfoot SM, et al. 2011. Immunity. 34:947-60.
- Sáez de Guinoa J, et al. 2011. Blood. 118:1560-9.
- Gene ID
- 643 View all products for this Gene ID
- UniProt
- View information about CD185 on UniProt.org
Related FAQs
Other Formats
View All CD185 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD185 (CXCR5) Recombinant Antibody | QA21A13 | FC |
| APC anti-human CD185 (CXCR5) Recombinant Antibody | QA21A13 | FC |
| PE anti-human CD185 (CXCR5) Recombinant Antibody | QA21A13 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD185 (CXCR5) Recombinant Antibody
Human peripheral blood lymphocytes were stained with purifie... -
APC anti-human CD185 (CXCR5) Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human CD185 (CXCR5) Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu...
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