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Purified anti-human CD196 (CCR6) Recombinant Antibody

Pricing & Availability
Clone
QA17A37 (See other available formats)
Regulatory Status
RUO
Other Names
BN-1, CKR6, DCR2, CKRL3, DRY-6, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, GPR-CY4
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA17A37_PURE_CD196_Antibody_032221
Human peripheral lymphocytes were stained with CD19 APC and purified CD196 (CCR6) recombinant (clone QA17A37 (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
  • QA17A37_PURE_CD196_Antibody_032221
    Human peripheral lymphocytes were stained with CD19 APC and purified CD196 (CCR6) recombinant (clone QA17A37 (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
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399002 100 µg £157
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Description

CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This recombinant antibody clone is derived from clone G034E3.

RRID
AB_2892469 (BioLegend Cat. No. 399002)

Antigen Details

Structure
Chemokine receptor, GPCR, seven transmembrane receptor
Distribution

Immature dendritic cells, B lymphocytes, memory T cells, Th17 cells

Function
Host defense, important for recruitment of B cells to secondary lymphoid organs, mediates arrest of T cells on dermal endothelial cells
Ligand/Receptor
CCL20 (MIP-3α)
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Zaballos A, et al. 1996. Biochem. Bioph. Res. Co. 227:846.
 2. Yang D, et al. 1999. Science 286:525.
 3. MacDonald KG, et al. 2007. Am. J. Pathol. 170:1229.
 4. Homey B, et al. 2000. J. Immunol. 164:6621.
 5. Hirota K, et al. 2007. J. Exp. Med. 204:2803.
 6. Singh SP, et al. 2008. J. Immunol. 180:214.

Gene ID
1235 View all products for this Gene ID
UniProt
View information about CD196 on UniProt.org
Go To Top Version: 1    Revision Date: 03/22/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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