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Purified anti-human CD198 (CCR8) Antibody

Pricing & Availability
Clone
S19017D (See other available formats)
Regulatory Status
RUO
Other Names
CC-CKR-8,C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
S19017D_PURE_CD198_Antibody_1_110421
Human peripheral blood lymphocytes were stained with purified CD198 (CCR8, clone S19017D) (left) or purified mouse IgG2a, κ isotype control (right), followed by goat-anti mouse IgG PE, then CD3 APC.
  • S19017D_PURE_CD198_Antibody_1_110421
    Human peripheral blood lymphocytes were stained with purified CD198 (CCR8, clone S19017D) (left) or purified mouse IgG2a, κ isotype control (right), followed by goat-anti mouse IgG PE, then CD3 APC.
  • S19017D_PURE_CD198_Antibody_2_110421
    Human peripheral blood lymphocytes were stained with Purified CD198 (CCR8, clone S19017D) (left) or Purified mouse IgG2a, κ isotype control (right), followed by goat-anti mouse IgG PE, then CD3 APC.
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365702 100 µg £177
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Description

CCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CCR8-transfectants
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone S19017D induces complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) on CCR8-transfected cells.

RRID
AB_2904395 (BioLegend Cat. No. 365702)

Antigen Details

Structure
Seven hydrophobic transmembrane domains
Distribution

Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons

Cell Type
Tregs
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Tiffany HL, et al. 1997. J. Exp. Med. 186:165.
  2. Goya I, et al. 1998. J. Immunol. 160:1975.
  3. Lee S, et al. 2000. J. Virol. 74:6946.
  4. Chensue SW, et al. 2001. J. Exp. Med. 193:573.
  5. Qu C, et al. 2004. J. Exp. Med. 200:1231.
  6. Isolam SA, et al. 2003. J. Exp. Med. 210:1889.
Gene ID
1237 View all products for this Gene ID
UniProt
View information about CD198 on UniProt.org
Go To Top Version: 1    Revision Date: 11/04/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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