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Purified anti-human CD1b Antibody

Pricing & Availability
Clone
SN13 (K5-1B8) (See other available formats)
Regulatory Status
RUO
Other Names
R1
Isotype
Mouse IgG1, κ
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Product Citations
publications
SN13_Pure_042408
Human T-lymphoblastic leukemia cell line Molt-4 stained with purified SN13, followed by anti-mouse IgG FITC
  • SN13_Pure_042408
    Human T-lymphoblastic leukemia cell line Molt-4 stained with purified SN13, followed by anti-mouse IgG FITC
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329102 100 µg £81
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Description

CD1b is a 43 kD member of the immunoglobulin superfamily also known as R1. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with β2-microglobulin. In humans, CD1 family consists of group I proteins (CD1a, CD1b, CD1c), group II (CD1d), and group III (CD1e). CD1b plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. It is expressed on cortical double positive and single positive thymocytes, Langerhans cells, and dendritic cells. In addition to antigen presentation, CD1b has been implicated in thymic T cell development.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Cynomolgus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Membrane antigen preparation of human thymocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F, IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Hayes SM, et al. 2001. J. Immunol. 166:403. (IF)
  2. Martin LH, et al. 1987. P. Natl. Acad. Sci. USA 84:918993. (IF)
Product Citations
  1. Guo T, et al. 2018. J Immunol. 200:500. PubMed
RRID
AB_961143 (BioLegend Cat. No. 329102)

Antigen Details

Structure
immunoglobulin superfamily
Distribution

cortical thymocytes, Langerhans cells, and dendritic cells

Cell Type
Dendritic cells, Langerhans cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Porcelli S, et al. 1992. Nature 360:5937.
2. Giuliani A, et al. 2001. Infect. Immun. 69:746170.

Gene ID
910 View all products for this Gene ID
UniProt
View information about CD1b on UniProt.org

Other Formats

View All CD1b Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-human CD1b SN13 (K5-1B8) FC,IHC-F,IP
FITC anti-human CD1b SN13 (K5-1B8) FC
PE anti-human CD1b SN13 (K5-1B8) FC
APC anti-human CD1b SN13 (K5-1B8) FC
TotalSeq™-B1468 anti-human CD1b SN13 (K5-1B8) PG
Go To Top Version: 2    Revision Date: 09/01/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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