Purified anti-human CD1c Antibody

Pricing & Availability
Clone
W18077D (See other available formats)
Regulatory Status
RUO
Other Names
R7, M241, BDCA-1, CD1
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W18077D_PURE_CD1c_Antibody_1_121323
Human peripheral blood lymphocytes were stained with anti-human CD19 APC and purified anti-human CD1c (clone W18077D) (left), or purified rat IgG2a, κ isotype control (right) followed by anti-rat IgG PE.
  • W18077D_PURE_CD1c_Antibody_1_121323
    Human peripheral blood lymphocytes were stained with anti-human CD19 APC and purified anti-human CD1c (clone W18077D) (left), or purified rat IgG2a, κ isotype control (right) followed by anti-rat IgG PE.
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389402 100 µg £137
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Description

CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
RBL1 cells expressing 1-328
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_3097363 (BioLegend Cat. No. 389402)

Antigen Details

Structure
3 kD, Ig superfamily, MHC I-like molecule, associates with β2-microglobulin
Distribution

B cell subset, cortical thymocytes, dendritic cells, and Langerhans cells

Function
Presents lipid antigen to CD1c-restricted T cells
Interaction
Expressed on B cells in lymph nodes, spleen, and blood
Ligand/Receptor
CD1c-restricted TCR
Cell Type
B cells, Dendritic cells, Langerhans cells, Thymocytes
Biology Area
Immunology
Molecular Family
CD Molecules
Gene ID
911 View all products for this Gene ID
UniProt
View information about CD1c on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12/13/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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