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Purified anti-human CD213a1 (IL-13Rα1) Antibody

Pricing & Availability
Clone
SS12B (See other available formats)
Regulatory Status
RUO
Other Names
NR4, CT19
Isotype
Mouse IgG1, κ
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Product Citations
publications
SS12B_Purified_IL-13Ra1_Antibody_FC_091213.jpg
IL-13Rα1 transfected Burkitt's lymphoma cell line (DND-39) were stained with purified IL-13Rα1 (clone SS12B, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • SS12B_Purified_IL-13Ra1_Antibody_FC_091213.jpg
    IL-13Rα1 transfected Burkitt's lymphoma cell line (DND-39) were stained with purified IL-13Rα1 (clone SS12B, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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360402 100 µg £185
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Description

CD213a1, also known as IL-13Rα1, is a subunit of the IL-13R complex. It can heterodimerize with IL-4R and bind IL-13 with high affinity. IL-13Rα1 by itself binds IL-13 with low affinity compared to IL-13Rα2. It is a 48.7 kD, single pass type I membrane protein. It is expressed at low levels on myeloid cells and on activated T and B cells and Th17 cells. It interacts with TYK2 and may lead to activation of JAK1, STAT3, and STAT6 that is induced by IL-13 and IL-4. It has been implicated to have a role in asthma and allergic responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant extracellular domain of human IL-13 receptor α1 chain
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2562552 (BioLegend Cat. No. 360402)

Antigen Details

Structure
Single-pass type I membrane protein 48.7 kD; forms a heterodimer with IL-4R
Distribution

Expressed at low levels on myeloid cells; also expressed on activated T and B cells, Th17 cells

Function
Functional receptor for IL-13
Interaction
Interacts with TYK2 and can lead to downstream activation of JAK1, STAT3, and STAT6
Ligand/Receptor
IL-13
Cell Type
B cells, T cells, Th17
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Aman MJ, et al. 1996. J. Biol. Chem. 271:29265.
2. Osawa M, et al. 2000. Immunogenetics. 51:974.
3. Arima K, et al. 2005. J. Biol. Chem. 280:24915.
4. LaPorte SL, et al. 2008. Cell. 132:259.
5. Newcomb DC, et al. 2011. J. Allerg. Clin. Immunol. 127:1006.

Gene ID
3597 View all products for this Gene ID
UniProt
View information about CD213a1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09/19/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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