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Purified anti-human CD217 Antibody

Pricing & Availability
Clone
W15177A (See other available formats)
Regulatory Status
RUO
Other Names
IL-17R, IL-17RA, IL-17AR, IL-17 receptor
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
W15177A_PURE_CD217_Antibody_093016
Human peripheral blood granulocytes stained with purified CD217 (clone W15177A, filled histogram), or mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
  • W15177A_PURE_CD217_Antibody_093016
    Human peripheral blood granulocytes stained with purified CD217 (clone W15177A, filled histogram), or mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
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372302 100 µg £213
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Description

Six interleukin-17 (IL-17)-family (IL-17A-IL-17F) and five IL-17 receptor (IL-17R)-family (IL-17RA-IL-17RE) members have been reported in mammalian cells. IL-17RA (known as IL-17R, IL-17AR, CD217) is a 128-158 kD type I transmembrane glycoprotein. IL-17R binds to IL-17A (also known as IL-17, and CTLA-8, is a hallmarker of Th17 cells) and IL-17F and mediates the proinflammatory signals through interaction with IL-17RC or IL-17RD. IL-17R has broad tissue distribution, including fibroblasts, epithelial cells, endothelial cells, stromal cells, B cells, T cells, NK cells, monocytes and granulocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
P3U1 cells stably transfected with CD217.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2632646 (BioLegend Cat. No. 372302)

Antigen Details

Structure
128-158 kD type I single transmembrane glycoprotein, homodimer or heterodimer with IL-17RC, or associate with IL-17RD.
Distribution

Broad tissue distribution, including fibroblasts, epithelial cells, endothelial cells, stromal cells, B cells, T cells, NK cells, monocytes and granulocytes

Function
Binds IL-17 and mediate IL-17 induced inflammatory responses.
Ligand/Receptor
IL-17A, IL-17F.
Cell Type
Eosinophils, Neutrophils
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Moseley TA, et al. 2003. Cytokine Growth Factor Rev. 14:155.
2. Rong Z, et al. 2009. Cell. Res. 19:208.
3. Toy D, et al. 2006. J. Immunol. 177:36.

Gene ID
23765 View all products for this Gene ID
UniProt
View information about CD217 on UniProt.org
Go To Top Version: 1    Revision Date: 10/03/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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