- Clone
- W15177A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- IL-17R, IL-17RA, IL-17AR, IL-17 receptor
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
372302 | 100 µg | £213 |
Six interleukin-17 (IL-17)-family (IL-17A-IL-17F) and five IL-17 receptor (IL-17R)-family (IL-17RA-IL-17RE) members have been reported in mammalian cells. IL-17RA (known as IL-17R, IL-17AR, CD217) is a 128-158 kD type I transmembrane glycoprotein. IL-17R binds to IL-17A (also known as IL-17, and CTLA-8, is a hallmarker of Th17 cells) and IL-17F and mediates the proinflammatory signals through interaction with IL-17RC or IL-17RD. IL-17R has broad tissue distribution, including fibroblasts, epithelial cells, endothelial cells, stromal cells, B cells, T cells, NK cells, monocytes and granulocytes.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- P3U1 cells stably transfected with CD217.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2632646 (BioLegend Cat. No. 372302)
Antigen Details
- Structure
- 128-158 kD type I single transmembrane glycoprotein, homodimer or heterodimer with IL-17RC, or associate with IL-17RD.
- Distribution
-
Broad tissue distribution, including fibroblasts, epithelial cells, endothelial cells, stromal cells, B cells, T cells, NK cells, monocytes and granulocytes
- Function
- Binds IL-17 and mediate IL-17 induced inflammatory responses.
- Ligand/Receptor
- IL-17A, IL-17F.
- Cell Type
- Eosinophils, Neutrophils
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Moseley TA, et al. 2003. Cytokine Growth Factor Rev. 14:155.
2. Rong Z, et al. 2009. Cell. Res. 19:208.
3. Toy D, et al. 2006. J. Immunol. 177:36. - Gene ID
- 23765 View all products for this Gene ID
- UniProt
- View information about CD217 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CD217 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
APC anti-human CD217 | W15177A | FC |
Purified anti-human CD217 | W15177A | FC |
PE anti-human CD217 | W15177A | FC |
PE/Cyanine7 anti-human CD217 | W15177A | FC |
TotalSeq™-B1451 anti-human CD217 | W15177A | PG |
TotalSeq™-C1451 anti-human CD217 | W15177A | PG |
TotalSeq™-A1451 anti-human CD217 | W15177A | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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APC anti-human CD217
Human peripheral blood granulocytes stained with CD217 (clon... -
Purified anti-human CD217
Human peripheral blood granulocytes stained with purified CD... -
PE anti-human CD217
Human peripheral blood granulocytes stained with CD217 (clon... -
PE/Cyanine7 anti-human CD217
Human peripheral blood granulocytes stained with anti-human ... -
TotalSeq™-B1451 anti-human CD217
-
TotalSeq™-C1451 anti-human CD217
-
TotalSeq™-A1451 anti-human CD217
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