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Purified anti-human CD224 Antibody

Pricing & Availability
Clone
KF29 (See other available formats)
Regulatory Status
RUO
Other Names
γ-Glutamyl transferase 1 (GGT1), γ-Glutamyl transpeptidase 1 (GGTP), GGT, GTG
Isotype
Mouse IgG1, κ
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Product Citations
publications
KF29_PURE_CD224_Antibody_061518
Human peripheral blood lymphocytes were stained with CD3 APC and purified CD224 (clone KF29) (left) or Mouse IgG1, κ isotype control (right), followed by anti-mouse IgG1 PE
  • KF29_PURE_CD224_Antibody_061518
    Human peripheral blood lymphocytes were stained with CD3 APC and purified CD224 (clone KF29) (left) or Mouse IgG1, κ isotype control (right), followed by anti-mouse IgG1 PE
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394302 100 µg £182
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Description

CD224, also known as γ-Glutamyl transferase 1 (GGT1), is a  type I gamma-glutamyltransferase, and a member of the threonine peptidase family. CD224 consistes of a 380 amino acid heavy chain and a 189 amino acid light chain, which are translated from a single mRNA. It protects cells from oxidative stress by participating in γ-glutamyl cycle. CD224 is expressed on subset of T cells, B cells, stem cell precursor, endothelial cells and epithelial cells. It expresses on kidney, duodenuma and small intestine.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2734484 (BioLegend Cat. No. 394302)

Antigen Details

Structure
Type I gamma-glutamyltransferase
Distribution

Subset of T cells, B cells, stem cell precursor, endothelial cells and epithelial cells

Function
Protects cells from oxidative stress by participating in γ-glutamyl cycle
Ligand/Receptor
Glutathione, GSH, Leukotriene C4, GSNO
Cell Type
B cells, Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Mizushima T, et al. 2016. BMC. Cancer. 16:411.
  2. Wang Q, et al. 2017. Oncotarget. 8(22): 36171–36184.
  3. Jiang Y, et al. 2016. Mol. Med. 13(5):3813-20.
  4. Karp DR, et al. 1999. Int. Immunol. 11(11):1791-800.
Gene ID
2678 View all products for this Gene ID
UniProt
View information about CD224 on UniProt.org
Go To Top Version: 1    Revision Date: 06/18/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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