Purified anti-human CD366 (Tim-3) Recombinant Antibody

Pricing & Availability
Clone
QA17A33 (See other available formats)
Regulatory Status
RUO
Other Names
T cell immunoglobulin and mucin domain containing protein 3, CD366
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA17A33_PURE_CD366_Antibody_042621
PHA-stimulated (3 days) human peripheral blood lymphocytes were stained with anti-human CD4 APC and purified anti-human CD366 (Tim-3) recombinant (clone QA17A33) (left) or purified anti-mouse IgG, κ isotype control (right), followed by goat anti-mouse IgG PE.
  • QA17A33_PURE_CD366_Antibody_042621
    PHA-stimulated (3 days) human peripheral blood lymphocytes were stained with anti-human CD4 APC and purified anti-human CD366 (Tim-3) recombinant (clone QA17A33) (left) or purified anti-mouse IgG, κ isotype control (right), followed by goat anti-mouse IgG PE.
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312302 100 µg £157
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Description

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2892379 (BioLegend Cat. No. 312302)

Antigen Details

Structure
Transmembrane protein containing immunoglobulin domain and mucin-like domain; can exist as a soluble form lacking mucin and transmembrane domains
Distribution

Activated T cells, preferentially on Th1 cells, monocytes, dendritic cells

Function
Plays a role in regulating macrophage activation, T cell apoptosis and immune tolerance
Ligand/Receptor
Galectin-9
Cell Type
Dendritic cells, Macrophages, Th1
Biology Area
Immunology, Inhibitory Molecules
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Das M, Zhu C, Kuchroo VK. 2017. Immunol Rev. 276(1):97-111.
2. Dixon KO, Das M, Kuchroo VK. 2018. Nat Genet. 0(12):1640-1641.

Gene ID
84868 View all products for this Gene ID
UniProt
View information about CD366 on UniProt.org
Go To Top Version: 1    Revision Date: 04/22/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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