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Purified anti-human CD36L1 (SCARB1, SR-BI) Antibody

Pricing & Availability
Clone
m1B9 (See other available formats)
Regulatory Status
RUO
Other Names
SR-BI, SRB1, SR-B1, SRBI, CLA-1, CLA1, HDLQTL6
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
m1B9_Purified_CD36L1_Antibody_FC_072814.jpg
Human monocyte-derived dendritic cells were stained with purified anti-human CD36L1 (clone m1B9, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • m1B9_Purified_CD36L1_Antibody_FC_072814.jpg
    Human monocyte-derived dendritic cells were stained with purified anti-human CD36L1 (clone m1B9, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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363201 100 µg £230
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Description

Scavenger receptor class B type I (SCARB1), also known as CD36L1, is an integral membrane protein found in numerous cell types and tissues that is mainly expressed in the liver and the adrenal glands. Its primary function is facilitating the uptake of cholesteryl esters from high-density lipoproteins (HDL) due to its high affinity to HDL. This function serves to lower the risk of development of atherosclerosis. SCARB1 is also able to bind to other lipoproteins such as LDL, OxLDL, and VLDL. SCARB1 is also likely to be involved in pathogen recognition through its recognition of mycobacteria and other viral proteins and regulates vitamin E levels in the tissue.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Williams JW, et al. 2019. Immunohorizons. 37:3. PubMed
RRID
AB_2564121 (BioLegend Cat. No. 363201)

Antigen Details

Structure
Integral membrane glycoprotein.
Distribution

Macrophages, hepatocytes, dendritic cells, adrenocortical cells, adipocytes, trophoblastic cells.

Function
Involved in the uptake of high density lipoproteins (HDL), phagocytosis of apoptotic cells, and pathogen recognition. Receptor target of the hepatitis C virus.
Ligand/Receptor
Phosphatidylserine, HDL, apoB-containing lipoproteins, LDL, vitamin E.
Cell Type
Macrophages, Dendritic cells
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Acton S, et al. 1996. Science. 5248:518.
2. Rigotti A, et al. 2003. Endocr. Rev. 24:357.
3. Valacchi G, et al. 2011. Ann. N. Y. Acad. Sci. 1229:E1.
4. Scarselli E, et al. 2002. EMBO J. 21:5017.
5. Mardones P, et al. 2002. J. Nutr. 132:443.

Gene ID
949 View all products for this Gene ID
UniProt
View information about CD36L1 on UniProt.org
Go To Top Version: 1    Revision Date: 08/21/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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