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- Clone
- QA21A26 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD83, HB15, hCD83, BL11
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human monocyte-derived dendritic cells (induced with GM-CSF and IL-4 and TNF-α) stained with purified anti-human CD83 recombinant (clone QA21A26) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by PE anti-mouse IgG.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 382902 | 100 µg | £126 | ||||
CD83, also known as B-cell activation protein and Cell surface protein HB15, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2927817 (BioLegend Cat. No. 382902)
Antigen Details
- Structure
- Ig superfamily, single chain transmembrane glycoprotein, 43 kD
- Distribution
-
Dendritic cells, Langerhan cells, activated B and T cells
- Function
- Membrane-bound CD83 is of immune stimulatory capacity, activates T-cells and is important for the generation of thymocytes; the soluble CD83 has the opposite effect and has an immune inhibitory capacity. The transmembrane domain of membrane-bound CD83 stabilizes MHC II, costimulatory molecules and CD28 in the membrane by antagonizing MARCH-family E3 ubiquitin ligases.
- Interaction
- Treg, Dendritic cells, B cells
- Cell Type
- B cells, Dendritic cells, Langerhans cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Zhou LJ, et al. 1992. J Immunol. 149:735-42.
- Zhang Z, et al. 2004. Protein Sci. 13:2819-24.
- Gene ID
- 9308 View all products for this Gene ID
- UniProt
- View information about CD83 on UniProt.org
Related FAQs
Other Formats
View All CD83 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD83 Recombinant Antibody | QA21A26 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD83 Recombinant Antibody
Human monocyte-derived dendritic cells (induced with GM-CSF ...
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